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脾氨肽联合布地奈德治疗过敏性鼻炎病儿的效果及对外周血辅助性T细胞17/调节性T细胞平衡和相关细胞因子水平的影响

李月冯佳丽王霁

河南省职工医院医学装备部河南郑州450000郑州市金水区总医院药剂科河南郑州450000

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关键词： 鼻炎,过敏性脾氨肽布地奈德辅助性T细胞17 调节性T细胞

摘要： 目的观察脾氨肽联合布地奈德治疗过敏性鼻炎病儿的效果并分析其对外周血辅助性T细胞17(Th17)/调节性T细胞(Treg)平衡及相关细胞因子水平的影响。方法选取2020年10月至2021年10月河南省职工医院收治的126例过敏性鼻炎病儿作为研究对象,按随机数字表法分为两组。对照组63例给予布地奈德鼻喷雾剂治疗,联合组63例采用脾氨肽口服溶液联合布地奈德鼻喷雾剂治疗,均治疗3个月。观察治疗前后临床症状变化、Th17/Treg、血清白细胞介素-6(IL-6)、白细胞介素-17(IL-17)、转化生长因子-β1(TGF-β1)水平及疗效,对比两组不良反应发生情况。结果与治疗前相比,治疗后两组各剂型亚组临床症状评分、Th17比例、Th17/Treg、IL-6、IL-17水平均降低(P<0.05);联合组各剂型亚组临床症状评分、Th17比例、Th17/Treg、IL-6、IL-17水平均低于对照组(P<0.05)。治疗后联合组片剂亚组IL-6水平为(107.59±12.38)ng/L低于对照组片剂亚组的(129.43±13.87)ng/L(P<0.05)。与治疗前相比,治疗后两组各剂型亚组Treg比例、TGF-β1水平均升高(P<0.05);联合组各剂型亚组Treg细胞比例、TGF-β1水平均高于对照组(P<0.05)。联合组总有效率为93.65%高于对照组的80.95%(P<0.05);两组各剂型亚组不良反应发生情况比较差异无统计学意义(P>0.05)。结论脾氨肽联合布地奈德治疗有助于缓解过敏性鼻炎病儿症状,调节外周血Th17/Treg平衡和相关细胞因子水平,疗效好且安全。

基于孟德尔随机化的IL-7和IL-7Rα与强直性脊柱炎的因果关系研究

王灿陈雨欣白锦琦李有贺培凤于琦

山西医科大学管理学院太原030001山西医科大学麻醉学院太原030001山西医科大学儿科医学系太原030001山西医科大学医学数据科学学院太原030001

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关键词： 强直性脊柱炎 IL-7 IL-7受体α 孟德尔随机化

摘要： 目的:使用孟德尔随机化(MR)方法评估IL-7和IL-7Rα与强直性脊柱炎(AS)之间的因果关系。方法:本研究基于全基因关联研究(GWAS)汇总数据,利用单核苷酸多态性(SNPs)构建工具变量(IV),分别采用逆方差加权法(IVW)、加权中位数法(WM)、MR-Egger分析评估IL-7/IL-7Rα与AS之间的因果关系。此外,进行了敏感性检验,包括异质性检验、多效性检验、留一分析和MR-PRESSO检验。结果:IL-7和IL-7Rα分别纳入了9个和5个可用于MR分析的IVs。IVW分析结果显示,IL-7和IL-7Rα与AS之间存在可靠的因果关系[IL-7:P=0.0252,OR(95%CI)=0.9994(0.9891~0.9999);IL-7Rα:P=0.0083,OR(95%CI)=1.0006(1.0002~1.0010)]。Cochrane's Q检验(IL-7:P=0.9997;IL-7Rα:P=0.9469)显示各研究均具有良好的同质性。留一法敏感性分析结果表明,因果关联未受到单个IV的强烈影响。MR-Egger回归截距分析进一步表明,本研究中水平多效性没有对因果效应产生偏差。结论:IL-7和IL-7Rα均与AS存在强烈的因果关联,其中IL-7是AS的保护因素,IL-7Rα是AS的危险因素。

TNF-α拮抗剂治疗儿童慢性复发性多灶性骨髓炎6例疗效观察

刘欣张子博李赫周宇辉张冰刘力

天津市儿童医院(天津大学儿童医院)综合内科(免疫方向)天津市儿童出生缺陷防治重点实验室天津300074

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关键词： TNF-α拮抗剂慢性复发性多灶性骨髓炎临床疗效儿童

摘要： 目的评价TNF-α拮抗剂治疗儿童慢性复发性多灶性骨髓炎(CRMO)的疗效与安全性。方法回顾性分析2021年6月至2023年5月医院收治的CRMO患儿的临床资料。结果共纳入6例CRMO患儿,男4例、女2例,均以骨痛起病,中位起病年龄9.5(8~10)岁,中位确诊年龄为11(10~12)岁。4例C-反应蛋白、白细胞介素-6及红细胞沉降率升高,3例抗核抗体阳性,1例人类白细胞抗原B27阳性。自发病至最后1次随访,6例患儿共发现92处骨骼受累病灶,以跗骨(32处,34.8%)、跖骨(14处,15.2%)、股骨(9处,9.8%)和胫骨(9处,9.8%)为主。6例患儿于确诊后均接受了双氯芬酸钠、甲氨蝶呤及阿达木单抗治疗,例1、2、4、6接受阿达木单抗40 mg/次(2周1次),例3、5接受阿达木单抗20 mg/次(2周1次);例1入院前有阿达木单抗用药史,病情复发后再次应用阿达木单抗疗效欠佳,调整用药为英夫利昔单抗200 mg/次(每次4 mg/kg,1个月1次),经治疗病情明显缓解。6例患儿经规律治疗3个月后,4例骨痛症状消失;而例1在接受英夫利昔单抗治疗8个月后骨痛消失,例4在接受阿达木单抗治疗4个月后骨痛消失。在随访过程中,所有患儿炎性指标恢复正常,影像学提示病灶较治疗前明显吸收或消失,未见TNF-α拮抗剂相关的药物不良反应。结论TNF-α拮抗剂治疗儿童CRMO可控制炎症、改善症状和影像学变化,在随访中未发现药物不良反应。

SIL-TAL1^(+)儿童急性T淋巴细胞白血病的临床分析

薛玉娟王毓张乐萍陆爱东贾月萍曾慧敏

北京大学人民医院儿科北京100044

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维普期刊数据库

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关键词： 急性T淋巴细胞白血病儿童 SIL-TAL1融合基因预后

摘要： 目的:探究SIL-TAL1融合基因阳性的儿童急性T淋巴细胞白血病(SIL-TAL1^(+)T-ALL)的临床和预后特征。方法:回顾性分析2010年1月至2018年12月我院儿科收治的110例初诊T-ALL患儿的临床资料,比较SIL-TAL1^(+)组和SIL-TAL1-组的临床特征、治疗反应和预后情况。结果:110例T-ALL患儿中,SIL-TAL1^(+)组有25例(22.7%),SIL-TAL1-组有85例(77.3%)。SIL-TAL1^(+)组的初诊白细胞计数明显高于SIL-TAL1-组(P<0.05),两组间的其他临床特征及治疗反应均无明显差异。SIL-TAL1^(+)组和SIL-TAL1-组的5年总生存(OS)率分别为80.0%和75.5%,5年无病生存(DFS)率分别为76.0%和72.9%,两组间OS率及DFS率比较差异均无统计学意义(P>0.05)。在初诊年龄<10岁的患儿中,SIL-TAL1^(+)组与SIL-TAL1-组的5年OS率分别为100%与75.1%,两组间的差异具有统计学意义(P<0.05)。结论:儿童SIL-TAL1^(+)T-ALL初诊时白细胞水平更高,临床疗效与SIL-TAL1-无显著差异。但在初诊年龄<10岁的T-ALL患儿中,SIL-TAL1^(+)组的长期生存率明显更优。

Prognostic value of procalcitonin and IL-6 with a composite model in moderate-severe traumatic brain injury

Xin-meng Li Zi-wei Liu Wei-yu Liu Gao-jian Su Xian-jian Huang

Department of Neurosurgery Shenzhen Institute of Translational Medicine The First Affiliated Hospital of Shenzhen University Shenzhen Second People's Hospital Shenzhen China

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PubMed期刊

关键词： Interleukin 6 Procalcitonin Traumatic brain injury Prognosis

摘要：

Background

Inflammation is a critical secondary injury mechanism in craniocerebral trauma, which contributes to further tissue damage and long-term neurological deficits. This inflammatory response is primarily a neurotoxic injury mediated through the production of inflammatory factors by the inflammatory cells. Among these, IL-6 is the most promising biomarker for the clinical diagnosis of brain injury, and procalcitonin (PCT) is a promising biomarker specific for bacterial infection. This study aimed to investigate the relationship between IL and 6 and PCT concentrations at admission and the Glasgow Outcome Score (GOS) at 6 months post-discharge in patients with moderate-to-severe traumatic brain injury (TBI).

Methods

This retrospective study included 122 patients with moderate-to-severe TBI (Glasgow Coma Scale [GCS] 3–12) admitted to Shenzhen Second People’s Hospital between January 2019 and June 2024. GOS scores at 6 months after discharge were recorded. Outco

(−)-Epigallocatechin Gallate Ameliorates Chronic Stress-Induced Depression-Like Behavior in Rats by Inhibiting the NF-κB/Caspase-1 Signaling Pathway and Reducing IL-1β and IL-18 Expression

Wu, Guixian Xu, Jieyu Wu, Wanhua Jin, Jian Li, Shanqian Huang, Yue Zhang, Zongyi Hu, Yue Zhang, Yulin Liu, Yuling Xu, Yao Zheng, Meimei Xu, Chaozhi Lu, Wenjun Wu, Hongxian Hu, Lina

School of Public Health Guilin Medical University Guilin ChinaGuangxi Key Laboratory of Environmental Exposomics and Whole Life Cycle Health Guilin ChinaKey Cultivation Laboratory of Life Cycle Health Care Research Guilin ChinaGuilin University of Aerospace Technology Guilin ChinaDepartment of Clinical Laboratory Guilin Social Welfare Hospital Guilin ChinaNutrition Department of Liuzhou Workers' Hospital Liuzhou ChinaDepartment of Pediatrics The First Affiliated Hospital of Guangxi Medical University Nanning ChinaCommunicable Disease Control Branch Qingdao City Center for Disease Control and Prevention Qingdao ChinaInstitute of Drug Inspection Technology Shanxi Inspection and Testing Center Taiyuan ChinaDepartment of Nutrition Second People's Hospital of Ya'an City Ya'an City ChinaMedical Information Management School of Humanities and Management Guilin Medical University Guilin ChinaGeneral Practice Department Affiliated Hospital of Guilin Medical University Guilin ChinaDepartment of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases Shanghai ChinaState Key Laboratory of Cardiovascular Diseases Zhongshan Hospital Fudan University Shanghai ChinaNHC Key Laboratory of Ischemic Heart Diseases Shanghai ChinaKey Laboratory of Viral Heart Diseases Chinese Academy of Medical Sciences Shanghai ChinaNational Clinical Research Center for Interventional Medicine Shanghai China

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PubMed期刊

关键词： chronic stress depression-like behaviors EGCG pyroptosis

摘要： This study aimed to further clarify the ameliorative effects of epigallocatechin-3-gallate (EGCG) on depression and depression-like behaviors induced by chronic unpredictable mild stress (CUMS) in female Sprague–Dawley (SD) rats. EGCG was administered via intraperitoneal injection, and liver function and blood lipid profiles were assessed. Western blot analysis was employed to determine the expression levels of caspase-1 and nuclear factor kappa B (NF-κB), as well as inflammatory factors interleukin-1β (IL-1β) and interleukin-18 (IL-18). The results showed that CUMS induced depression-like behaviors (including anhedonia and behavioral despair) in rats, accompanied by reduced body weight, decreased liver index, and dyslipidemia. Western blot analysis revealed significantly elevated expression of pyroptosis-related proteins (NF-κB, cleaved-caspase-1, IL-1β, and IL-18) in both the liver and brain tissues of the CUMS group. EGCG treatment could reverse these results. Notably, female rats exhibited more severe CUMS-induced depression-like behaviors than male rats. These findings suggest that EGCG can alleviate CUMS-induced depression-like behaviors (anhedonia and behavioral despair) in female rats. This protective effect may be mediated by inhibiting the NF-κB/caspase-1 pyroptosis pathway, reducing IL-1β and IL-18 expression, thereby improving hepatocellular pyroptosis and alleviating liver injury. © 2025 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC.

维持性血液透析患者血清中性粒细胞明胶酶相关脂质运载蛋白、中性粒细胞/淋巴细胞、甲状旁腺素水平变化及并发感染病原菌分布和预后分析

张解孙婷婷马聪张雪

青岛市胶州中心医院血液净化中心山东青岛266300青岛市胶州中心医院肾病风湿免疫科山东青岛266300

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关键词： 维持性血液透析中性粒细胞明胶酶相关脂质运载蛋白中性粒细胞/淋巴细胞比值甲状旁腺素病原菌预后

摘要： 目的:探讨维持性血液透析(MHD)患者血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、中性粒细胞/淋巴细胞比值(NLR)、甲状旁腺素(PTH)水平变化及并发感染病原菌分布和预后分析。方法:选取MHD患者189例为MHD组,按感染情况分为感染组(n=103)和非感染组(n=86),感染组依据预后情况分为预后良好组(n=78)和预后不良组(n=25),另选85例同期健康体检者为对照组。比较各组血清NGAL、NLR、PTH水平及病原菌分布情况,Logistic回归分析MHD患者预后不良的危险因素。结果:MHD组患者血清NGAL、NLR、PTH水平明显高于对照组(均P<0.05),感染组患者血清NGAL、NLR、PTH水平明显高于非感染组(均P<0.05)。103例感染患者共检出94株病原菌,以革兰阴性菌为主,革兰阴性菌、革兰阳性菌分别有59株(62.77%)、29株(30.85%),真菌6株,占比6.38%。与预后良好组比较,预后不良组患者糖尿病、多重耐药菌感染患者占比及血清NGAL、NLR、PTH水平明显升高(均P<0.05)。糖尿病、多重耐药菌感染、高血清NGAL、NLR、PTH水平是MHD患者预后不良的危险因素(均P<0.05)。结论:MHD患者血清NGAL、NLR、PTH水平明显升高,感染致病菌以革兰氏阴性菌为主,糖尿病、多重耐药菌感染、高血清NGAL、NLR、PTH水平是MHD合并感染患者预后不良的危险因素。

CD19/CD73在慢性淋巴细胞白血病中的表达及与临床特征的相关性

汪彦屿刘兰赵玉洁石耿辉闵迅

遵义医科大学附属医院检验科贵州遵义563003遵义医科大学附属医院血液科贵州遵义563003

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关键词： CD19/CD73 慢性淋巴细胞白血病诊断脾肿大临床特征

摘要： 目的:探讨CD19/CD73在慢性淋巴细胞白血病(CLL)中的表达及与临床特征的相关性。方法:回顾性分析2022年1月至2023年11月我院收治的60例CLL患者以及40例同期健康志愿者(对照组)的临床资料,流式细胞术检测CLL患者外周血CD19、CD73的水平,并用Kaplan-Meier法对患者进行生存分析。结果:CLL组的血红蛋白、CD19/CD73均显著低于对照组,而CD19、CD73、β_(2)-MG显著高于对照组(均P<0.001)。经ROC曲线分析,CD19/CD73对CLL诊断的AUC值为0.980(95%CI:0.949-1.000,P<0.05),特异度为92.50%,敏感度为98.30%。脾肿大的CLL患者的CD19/CD73明显小于非脾肿大的患者(P<0.01)。CLL患者CD19/CD73与血红蛋白无显著相关性(r=0.056,P>0.05),与β_(2)-MG存在正相关性(r=0.837,95%CI:0.7402-0.8996,P<0.01)。根据CD19/CD73的中位数12.84将患者分为高、低表达两组,Kaplan-Meier生存曲线分析结果显示,低表达组18个月的总生存率和无进展生存率分别为87.08%、93.25%,高表达组分别为96.41%、99.90%,两组比较差异有统计学意义(均P<0.05)。结论:CD19/CD73在CLL患者机体中呈低水平,可作为CLL临床诊断的辅助指标,CD19/CD73与患者脾肿大密切相关,CD19/CD73低表达预示预后不良。

围手术期血清hs-CRP、IL-10、IFN-γ与冠心病患者PCI术后发生心肌损伤的相关性分析

李鸿杰黄晶王璐

信阳职业技术学院附属医院心内科河南信阳464000信阳职业技术学院护理学院河南信阳464000

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关键词： 冠心病经皮冠状动脉介入治疗心肌损伤超敏C-反应蛋白白细胞介素-10 γ-干扰素

摘要： 目的探讨围手术期超敏C-反应蛋白(hs-CRP)、白细胞介素-10(IL-10)、γ-干扰素(IFN-γ)与冠心病患者经皮冠状动脉介入治疗(PCI)后发生心肌损伤的相关性分析。方法选取2020年1月至2024年12月在信阳职业技术学院附属医院行PCI术的220例冠心病患者,根据其术后是否发生心肌损伤分为发生组(n=106)和未发生组(n=114)。比较两组患者的临床资料及血清生化指标水平,分析影响冠心病患者PCI术后发生心肌损伤的危险因素,并绘制受试者工作特征(ROC)曲线,采用曲线下面积(AUC)评估血清hs-CRP、IL-10、IFN-γ对冠心病患者PCI术后发生心肌损伤的诊断价值。结果 220例冠心病患者中,有106例患者PCI术后发生心肌损伤,其发生率为48.18%(106/220)。发生组年龄> 60岁、手术时间过长、术中并发无复流/慢血流、冠状动脉多支病变、支架植入≥2个及总长度≥35 mm占比、Gensini评分水平均高于未发生组(P<0.05)。术前1天,发生组与未发生组血清hs-CRP、IL-10、IFN-γ、血脂生化指标HDL-C、LDL-C、Apo B基线水平比较,差异无统计学意义(P > 0.05)。PCI术后1天,发生组hs-CRP、IFN-γ、Apo B水平均高于未发生组,IL-10水平低于未发生组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,年龄(OR=2.298,95%CI:1.135~4.651)、手术时间(OR=2.524,95%CI:1.148~5.547)、术中并发无复流/慢血流(OR=2.815,95%CI:1.327~5.971)、冠状动脉病变支数(OR=2.375,95%CI:1.483~3.804)、Gensini评分(OR=2.340,95%CI:1.359~4.029)、支架植入个数(OR=2.612,95%CI:1.401~4.869)、支架植入总长度(OR=2.399,95%CI:1.327~4.337)、术后hs-CRP(OR=3.445,95%CI:1.620~7.325)、术后IL-10(OR=0.600,95%CI:0.492~0.703)、术后IFN-γ(OR=2.784,95%CI:1.335~5.800)及术后Apo B(OR=2.375,95%CI:1.074~5.253)均为冠心病患者PCI术后发生心肌损伤的影响因素。ROC曲线分析显示,血清hs-CRP、IL-10、IFN-γ三者联合诊断价值最高(AUC=0.832,灵敏度78.67%,特异度89.46%)。结论术后血清hs-CRP、IL-10、IFN-γ联合检测对PCI术后心肌损伤具有较高的诊断价值,其诊断效能优于单一指标。

Acrodermatitis continua of Hallopeau—clinical review and proposed management algorithm

Matilde Iorizzo Shari R. Lipner Bianca Maria Piraccini Bertrand Richert Michela Starace Antonella Tosti

Private Dermatology Practice Bellinzona/Lugano SwitzerlandDepartment of Dermatology Weill Cornell Medicine New York City New YorkDermatology Unit IRCCS Azienda Ospedaliero-Universitaria di Bologna Bologna ItalyDepartment of Medical and Surgical Sciences University of Bologna Bologna ItalySaint Pierre-Brugmann and Queen Fabiola Children’s University Hospitals Université Libre de Bruxelles Brussels BelgiumDepartment of Dermatology and Cutaneous Surgery Miller School of Medicine University of Miami Miami Florida

来源 PubMed期刊详细信息

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PubMed期刊

关键词： acrodermatitis continua Hallopeau nail nail disorders psoriasis pustular psoriasis pustules treatment ACH acrodermatitis continua of Hallopeau AIKD autoinflammatory keratinization disease GPP generalized pustular psoriasis IL interleukin PP pustular psoriasis PPP palmo-plantar pustolosis PsA psoriatic arthritis PV psoriasis vulgaris TNF- α tumor necrosis factor-α

摘要：

Acrodermatitis continua of Hallopeau (ACH) is a rare inflammatory condition primarily affecting the fingers. It is characterized by painful paronychia with sterile pustules on an erythematous base around the nail folds and in the nail bed, which can progress to nail deformation and atrophy. In severe cases, resorptive osteolysis is a possible sequela. ACH is characterized by an inflammatory response resulting from innate immunity hyperactivation. Genetic mutations play a significant role in its pathogenesis, with the IL-36RN gene (mutated in 20% of cases) most often implicated. Treatment of ACH is challenging, with a low response to therapies. Systemic treatment is generally preferred, even in cases with localized presentation, and topical medications are considered only supportive. Acitretin is recommended as first-line treatment, although the disease often relapses, necessitating a more targeted therapeutic approach. Biologic drugs show good efficacy, but even these do not provide long-lasting remission. Despite emerging therapeutic options, ACH remains difficult to treat, and further research is needed to identify more effective strategies, including molecular profiling of the inflammatory infiltrate for a more personalized treatment.

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