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关键词： HLA   HLA-A*68:331   novel allele   sequencing-based typing  

摘要： HLA-A*68:331 differs from HLA-A*68:01:02:02 by one nucleotide substitution in codon 52 in exon 2.

关键词： full-length sequence   HLA-B   next-generation sequencing   novel allele   south India  

摘要： One nucleotide change (C -> T) in intron 1 of HLA-B*13:01:01:01 results in the novel HLA allele HLA-B*13:01:01:12.

关键词： Benign prostatic hyperplasia   Elderly   Homocysteine   IL-6   Diagnosis  

摘要： Objective: To investigate the diagnostic value of serum metabolic markers such as HCY, sdLDLC, Crea, inflammatory factor IL-6 and prostate-specific antigen in elderly patients with prostatic hyperplasia (BPH). Methods: 150 senile patients with hyperplasia of prostate were selected as observation group and 169 healthy senile patients were selected as control group. The tPSA, fPSA, fPSA/tPSA and prostate size data of the two groups were collected, and serum samples of the subjects were collected for the detection of HCY, sdLDL, Crea, IL-6 and other indicators. Univariate analysis, correlation analysis and logistic regression analysis were conducted to analyze the relationship between each index and senility prostatic hyperplasia. The diagnostic efficiency of each serum metabolite was analyzed by receiver operating characteristic curve (ROC). Results: Serum levels of tPSA, fPSA, Crea, HCY, sdLDL-C and IL-6 were significantly increased, fPSA/tPSA ratio and HDL were significantly decreased, and TCHO, TG and LDL had no statistical significance. Serum tPSA and fPSA levels were positively correlated with prostate size, serum IL-6, Crea and HCY levels were positively correlated with tPSA and fPSA levels, and serum sdLDL-C levels were negatively correlated with fPSA levels. Logistic regression analysis showed that tPSA, fPSA, prostate size, HCY, Crea and IL-6 were risk factors for prostate hyperplasia. HDL and fPSA/tPSA are protective factors for benign prostatic hyperplasia. ROC curve analysis showed that the sensitivity and specificity of fPSA/tPSA and IL-6 were 82.7% and 72%, 83.4% and 80.5%, and the area under ROC curve were 0.840 and 0.825, respectively. tPSA and fPSA combined with HCY, IL-6 and Crea had the best diagnostic efficiency, with the area under ROC curve reaching 0.881, specificity and sensitivity reaching 84% and 77.3%, respectively. Conclusion: The combined detection of prostate-specific antigen, HCY, Crea and IL-6 can significantly improve the diagnostic ef

关键词： microplastics   trace elements   environmental