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关键词： activated T cells   allogeneic stem cell transplantation   biomarker   chronic GvHD   flow cytometry  

摘要： Chronic graft vs host disease (cGvHD) is a major late determinant of transplant related mortality (TRM) after allogeneic hematopoietic stem cell transplantation (HSCT). We investigated the predictive value of peripheral blood activated HLA-DR(+)CD3(+) T cells as a novel biomarker. In total, 107 patients were included in this retrospective analysis. Peripheral blood HLA-DR(+)CD3(+) T cells were measured by flow cytometry 3 mo after HSCT. A HLA-DR(+)CD3(+) T cell count <140 cells/L at month 3 after HSCT correlated significantly with an increased TRM. A HLA-DR(+)CD3(+) T cell count <100 cells/L was associated with a higher rate of cGvHD grade 2 to 3. Subgroup analyses revealed significant results for TRM and cGvHD grade 2 to 3 for patients with a reduced intensity conditioning. In summary, low HLA-DR(+)CD3(+) T cells in the peripheral blood 3 mo after HSCT may represent a novel biomarker to identify patients with an increased risk for TRM and cGvHD grade 2 to 3.

关键词： Cancer   Biotechnology   Drug discovery   Gene therapy   Immunology   Therapeutics