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关键词： biologic agents   psoriasis   treatment interruption  

摘要： Background and objectivesContinuous biologic treatment is recommended for patients with psoriasis;however, treatment interruption in daily practice is inevitable. The impact of treatment interruption is difficult to study in a real-world setting. In Taiwan, biologics are reimbursed by the National Health Insurance for moderate-to-severe psoriasis for a 2-year course, followed by regulatory discontinuation. Thus, our study provides pragmatic data on the impact of the interruption of biologics treatment for non-medical reasons on therapy *** and methodsThis single-center retrospective cohort study recruited patients who underwent two consecutive 2-year courses of biologics between 2012 to *** total of 192 treatment courses from 61 patients were analyzed, with secukinumab and ustekinumab being the most frequently administered biologics. Among patients who continued with the same biologic across two consecutive courses, the time to achieve PASI 75 was shorter during the first course compared to the second, while overall maintenance effects remained similar. Switching to a different biologic usually produced superior results in the second course of *** the overall effectiveness after interruption and resumption of treatment with secukinumab or ustekinumab was comparable, the time to achieve PASI 75 was longer following an interruption. Continuous, uninterrupted treatment with a given biologic is therefore recommended whenever possible.

关键词： Interleukin-1 inhibition   periodic fever syndromes   TRAPS   TNFRSF1A gene   systemic autoinflammatory diseases  

摘要： Background/Aims: Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal dominant systemic autoinflammatory disease caused by mutations in the TNFRSF1A gene. The clinical presentation of TRAPS is heterogeneous, which can complicate its diagnosis. This study aimed to characterize the clinical and genetic features of patients with TRAPS diagnosed and treated in Slovakia, as well as to evaluate their therapeutic response to canakinumab. Materials and Methods: A retrospective analysis of clinical data from the Slovak national database of patients with periodic fever syndromes was performed, including 7 TRAPS patients diagnosed between 2019 and 2022 in Slovakia. These data were compared with findings from available cohorts from Europe, China, and Japan. Results: All 7 patients were female, with a median age at clinical disease onset of 6 years (range: 8 months to 30 years);1 patient had adult-onset disease. The most frequent symptoms were recurrent episodes of fever (6/7), skin rash (6/7), arthralgia (6/7), myalgia (5/7), abdominal pain (4/7), chest pain (4/7), and general fatigue (4/7). Notably,1 patient exhibited central nervous system (CNS) involvement manifesting as seizures and aseptic CNS inflammation. Genetic analysis identified 4 variants in TNFRSF1A, including the N145S variant (also referred to as N116S), a variant only rarely reported in the *** canakinumab resulted in a significant reduction in flare frequency and decreases in inflammatory markers. Conclusion: This study underscores the phenotypic diversity of TRAPS, as shown by the identification of the rare TNFRSF1A N145S variant and a case with CNS involvement. The estimated prevalence of TRAPS in Slovakia is approximately 1 : 780 000, and the clinical features of these patients are comparable to those reported in European cohorts. Furthermore, the favorable therapeutic response to canakinumab supports its potential as an effective treatment option for TRAPS

关键词： mouse   heart transplant   rejection   MHC   disparity   heart transplantation in mice   ischemia-reperfusion injury   acute cellular rejection   antibody-mediated rejection   chronic rejection   immunosuppression   monotherapies   tacrolimus   CsA   rapamycin   mycophenolate mofetil  

摘要： Heart transplantation in mice has served as a reliable in vivo model in transplant research worldwide for more than half a century. It is not only useful for addressing cardiac graftspecific questions but also provides mechanistic insights and therapeutic strategies that have a broad impact across all solid organ transplants. Compared to other mouse models of solid organ transplantation, such as kidney, lung, or small intestine transplants, the surgical techniques to perform mouse heart transplantation (mHT) are relatively easy to master, and the graft heartbeat offers a simple means to evaluate transplant viability. However, as with other in vivo mouse models, mHT has distinct strengths and limitations. Multiple factors can influence the accuracy and reproducibility of the results, including microsurgical techniques and microsurgeons' skills, postoperative monitoring methodologies, mouse strain combinations, and sex/age. As innovative biotechnologies continue to emerge, the future holds many opportunities for preclinical research utilizing the mHT model. It is therefore imperative to provide the field with optimized mHT protocols and maintain standard reporting requirements. This minireview provided a concise summary and recommendations for standardized practices to ensure the accuracy, reproducibility, and translational value of findings generated from the mHT model.

关键词： HLA antibody   Compatible platelets   Transfusion support   Platelet matching software   Donor specific antibody  

摘要： Transfusion support for sensitized patients is an important function of blood centers and HLA laboratories. However, access to widely available software to facilitate matching patients with compatible donor units is limited. We developed vendor-supported and integrated software that interfaces with the laboratory informatics system, sourcing typing data from our platelet donor registry and retrieving patient HLA typing and unacceptable antibody specificities. The application filters antigen-negative donors and ranks them using an algorithm that incorporates HLA match, donor homozygosity, and cross-reactive group comparison for mismatched antigens, and generates a customizable report of ranked donors for the blood center. Low, moderate, and high antibody reactivities can be filtered to better support highly sensitized patients. Implementing vendor-supported software ensures continued maintenance, support, and the opportunity for updates with evolving platelet matching protocols. This customizable solution reduces transcription errors and streamlines data retrieval, allowing provision of timely and efficient transfusion support for patients.

关键词： neuroimmunomodulation   subfornical organ   gut   white adipose   CD4+ T cells   IFN-γ   CXCR6  

摘要： The constitutive presence of immune cells within brain parenchyma under homeostatic conditions is debated. Recent findings by Yoshida et al. have shown that the subfornical organ harbors gut-and adipose-derived T cells that secrete IFN-gamma to regulate brain homeostasis and adaptive behavior in the gut-fat-brain immune axis.