课程文献中心 更多>>

关键词： ASIA   silicone   granuloma   adalimumab   anti-TNF  

关键词： maternal infant health   Staphylococcus aureus   skin infection   vaccine   colonization  

摘要： Background Staphylococcus aureus is the leading cause of infectious-related deaths. Vaccine development has been hampered by the recall of nonprotective immune responses from prior exposure, suggesting an effective vaccine may need to be given early in life. The goal of this pilot study was to correlate the maternal serologic response against S. aureus to an infant's risk for skin and soft tissue infection (SSTI) and colonization in the first year of *** Pregnant women were enrolled and maternal-infant dyads followed for 12 months. Maternal third trimester and cord blood were obtained to determine the anti-S. aureus IgG and anti-alpha-toxin (Hla) neutralizing antibody (NAb) titers. Serial surveys and skin swabs were obtained from mothers at enrollment and from infants longitudinally to ascertain S. aureus colonization status and the incidence of *** Sixty-three pregnant women were enrolled, 54% with history of SSTI or asymptomatic S. aureus colonization at enrollment. Within 48-h of delivery, 23% of infants had S. aureus colonization and 43% at 1-month. Maternal S. aureus colonization resulted in 7.4 increased odds of infant colonization at delivery. Higher cord blood anti-Hla Nab titer was associated with significantly lower risk for infant SSTI in the first year of *** S. aureus colonization occurs early in life, with over 40% of infants colonized by 1-month. These results are the first to demonstrate an association between higher transplacental anti-Hla NAb and protection against infant SSTI in the first year of life. Overall, these findings support Hla as a promising vaccine target. Staphylococcus aureus is a significant cause of mortality. In a prospective cohort study of maternal-infant dyads, higher cord blood anti-Hla neutralization antibody titers correlated with decreased infant infection, suggestion this may be a promising correlate of protection for vaccine development.

关键词： Obstructive sleep apnea   Claudin-4   IL-22   Intestinal repair  

摘要： Background: Obstructive sleep apnea (OSA) is characterized as a low-grade inflammatory condition resulting from injury induced by intermittent hypoxia (IH). Interleukin-22 (IL-22), a mucosa-targeting cytokine, regulates tight junction proteins like Claudin-4 (CLDN4) to enhance barrier function, yet its role in OSA remains underexplored. Methods: This pilot observational study included consecutive patients who underwent polysomnography. Plasma IL-22 and CLDN4 levels were measured using an enzyme-linked immunosorbent assay. Rat models of IH-exposed colon tissues were used for histology and immunohistochemical analysis. All statistical analyses were performed using SPSS 20.0. Results: The expression of plasma IL-22 and CLDN4 was found to be positively correlated in OSA patients (r = 0.512, p < 0.001). Plasma IL-22 and CLDN4 levels exhibited a significant positive correlation with the apnea-hypopnea index (both p < 0.001), arousal index (p = 0.001 and p = 0.014), oxygen desaturation index (p < 0.001 and p = 0.001), and T90 (r = 0.379, p < 0.001 and p = 0.002). They also exhibited significant negative correlations with sleep efficiency (0.029;p = 0.004), REM sleep phases (p = 0.037 and p = 0.015), and mean oxygen saturation (SpO(2)) (p = 0.044 and p = 0.006). Plasma IL-22 and CLDN4 were significantly increased in the OSA group (p < 0.001), especially in severe OSA. The diagnostic value of plasma IL-22 combined with CLDN4 was superior to that of other indicators, with an AUC of 0.849 (0.783-0.915) for diagnosing OSA and an AUC of 0.909 (0.856-0.961) for diagnosing severe OSA. Pathological staining of the rat colon confirmed the damage of intermittent hypoxia (IH) to the intestine. The rat IH group had more IL-22 in the intestinal lymph node and more CLDN4 in the intestinal epithelium than the normal control (NC) group. The expression trends of IL-22 and CLDN4 in rat plasma were consistent with those observed in tissue samples. Conclusion: Plasma IL-22 and CLDN4 were assoc

摘要： Introduction: Hidradenitis suppurativa is a chronic, relapsing inflammatory skin disease associated with comorbidities and detrimental impact on the quality of life of patients. Painful inflammatory nodules, abscesses and draining tunnels are the ...

关键词： B cell   chronic rhinosinusitis with nasal polyps   ectopic lymphoid tissue   IgE   IL-4 receptor alpha chain