关键词:
Anisometropic amblyopia
Acupuncture
Resting-state fMRI
Visual"what"pathway
Amplitude of low frequency fluctuation
Regional homogeneity
摘要:
Objective:To evaluate the effect of acupuncture on anisometropic amblyopia(AA)and explore its potential mechanism for children with ***:Seventy-six children with monocular AA were randomized into a conventional treatment group and a combined treatment group of acupuncture and conventional treatment,with 38 patients in each *** the conventional treatment group,on the base of patching regimen,the red flashing,grating and visual stimulation were *** approach lasted for 5 min per session and was given once every two days,three times a week,for 4 consecutive *** the acupuncture-combined treatment group,on the base of the regimen of conventional treatment group,acupuncture was applied to Jingming(BL1),Cuanzhu(BL2),Fengchi(GB20)and Guangming(GB37),with needles retained for 20 min per session,once every two days,three times of intervention a week and for 4 consecutive *** and after treatment,the best corrected vision acuity(BCVA)was observed to evaluate the clinical effect in the two *** treatment started,15 patients with AA on left side were randomized selected from each group and the resting-state functional magnetic resonance imaging(rs-fMRI)was operated before and after ***,eight healthy children with normal visual acuity were recruited to be the normal control group and received one-time rs-fMRI *** on the activation likelihood estimation(ALE),the visual"what"pathway network was *** analyzing the amplitude of low frequency fluctuation(ALFF)and the regional homogeneity(ReHo),the differences in the regional autonomous function activities in the key brain areas of the"what"pathway were compared among the three ***:(1)Clinical effect:After treatment,BCVA was(0.6[0.5,0.6]),higher than that(0.4[0.3,0.5])before treatment,presenting the statistical difference(P<0.05)in the conventional treatment *** was(0.6[0.6,0.8]),higher than that(0.4[0.4,0.5])before treatment,present