关键词： Neutron gamma density   Characteristic capture gamma rays   Boron sleeve gamma detector   Boron-10 element   Formation water salinity  

摘要： Neutron gamma density measurement using dual gamma detectors (NGD-GD) is a popular density measurement method. Compared with other NGD methods, the NGD-GD method has many advantages in tool optimization, cost control, and density precision;however, it is easily affected by the salinity of formation water. To improve the NGD-GD method, the influence mechanism of formation water salinity was discussed, and a feasible improvement scheme using characteristic gamma information was proposed. A special boron sleeve gamma detector was designed to record the capture gamma rays from the boron-10 element. By analyzing the gamma spectrum, pure boron-10 gamma information was extracted from the total capture gamma spectrum for density calculation. Finally, a new NGD method with boron sleeve gamma detectors (NGD-BD) was developed. Results depict that although the NGD-BD method has a slight decrease in density accuracy and precision compared with the NGD-GD method, its performance is significantly improved in high-brine formations, and oil and gas formations. In addition, the NGD-BD method exhibits better performance in terms of density accuracy, density precision, and environmental impact than another NGD method that uses hydrogen capture gamma information. Moreover, the NGD-BD method is easily implemented with low cost and has little impact on existing NGD tools, and hence, it can coexist with other NGD methods to improve logging quality. Overall, the NGD-BD method is a very promising alternative to the NGD-GD method.

关键词： Modified Holling-Tanner model   Alternative food   Turing instability   Turing patterns  

摘要： In this manuscript, we consider temporal and spatio-temporal modified Holling-Tanner predator-prey models with predator-prey growth rate as a logistic type, Holling type II functional response and alternative food sources for the predator. From our result of the temporal model, we identify regions in parameter space in which Turing instability in the spatio-temporal model is expected and we show numerical evidence where the Turing instability leads to spatio-temporal periodic solutions. Subsequently, we analyse these instabilities. We use simulations to illustrate the behaviour of both the temporal and spatiotemporal model. (c) 2021 Elsevier B.V. All rights reserved.

关键词： Access to electricity   Energy use trend   Supply-demand gap   Energy diversification barriers   Policy & governance  

摘要： Providing uninterrupted and reliable electricity to all at an affordable price is a major undertaking for the governments of increasingly energy-hungry countries. This study assesses the energy supply-demand gap, progress, and prospects of alternative energy sources in Bangladesh. Several methods, including descriptive, trend, and comparative analyses, were carried out using time-series energy data to determine the current and historical energy status. Results show that between 1990 and 2018, the country experienced an approximate 3.05-fold increase in energy consumption from 12,743 to 38,807 ktoe, and a 3.11-fold increase in energy pro-duction from 10,760 to 33,504 ktoe. The shortfall between supply and consumption is approximately 26%, but this can be resolved by addressing energy diversification barriers related to policy, governance through regu-latory actions, investment, transmission and distribution, resources optimisation, energy efficiency, conserva-tion, research and education, and regional cooperation.

关键词： Lung   Bronchopulmonary dysplasia   Hyperoxia   Vasoactive intestinal peptide   Pituitary adenylate cyclase-activating polypeptide   Preterm newborns  

摘要： The use of oxygen therapy (high doses of oxygen hyperoxia) in the treatment of premature infants results in their survival. However, it also results in a high incidence of chronic lung disease known as bronchopulmonary dysplasia, a disease in which airway hyper-responsiveness and pulmonary hypertension are well known as consequences. In our previous studies, we have shown that hyperoxia causes airway hyper-reactivity, characterized by an increased constrictive and impaired airway smooth muscle relaxation due to a reduced release of relaxant molecules such as nitric oxide, measured under in vivo and in vitro conditions (extra-and intrapulmonary) airways. In addition, the relaxation pathway of the vasoactive intestinal peptide (VIP) and/or pituitary adenylate cyclase activating peptide (PACAP) is another part of this system that plays an important role in the airway caliber. Peptide, which activates VIP cyclase and pituitary adenylate cyclase, has prolonged airway smooth muscle activity. It has long been known that VIP inhibits airway smooth muscle cell proliferation in a mouse model of asthma, but there is no data about its role in the regulation of airway and tracheal smooth muscle contractility during hyperoxic exposure of preterm newborns.

摘要： In 2020, the National Resident Matching Program (NRMP) sponsored the inaugural "Single Match"-the first time that seniors and graduates of U.S. MD-granting and DO-granting schools participated in one Match. In honor of the Single Match milestone, the authors examine the NRMP's history, reflecting on the organization's efforts since the 1950s to support learners and the graduate medical education community by fostering a responsive, robust matching program while remaining true to its founding principles to provide parity of experience for applicants and reduce coercive practices. The chaos and stress associated with the pre-Match days in the 1920s and 1930s that led to the call for a national clearinghouse are highlighted as are significant NRMP accomplishments, from the organization's incorporation as a 501(c)(3) organization in 1953 as a simple internship placement system through the first Single Match. Recognizing that the current transition to residency is not without its stressors, the authors note that the NRMP remains committed and willing to continue to evolve and identify innovative and meaningful ways to address learner needs and improve the transition to residency.

关键词： COVID-19   SARS-CoV-2   Kawasaki-like   Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS)   Bibliometric   Preprint   Multisystem inflammatory syndrome in children (MIS-C)  

摘要： Introduction: At the end of April 2020, three European pediatric societies published an alert on a new hyperinflammatory disorder linked to SARS-CoV-2. This disease has alternatively been called Kawasaki-like disease, pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS), and multisystem inflammatory syndrome in children (MIS-C). These alerts provide a clear starting point from which to study the early response of the medical and scientific community to a new disease in terms of scientific publications, and to compare the timeline of this response with levels of general public interest. To this aim, we conducted a bibliometric analysis of articles on this disease published between 1 April and 5 July 2020. Method: A literature search was performed using PubMed and in three preprint repositories. For each article, the name used for the disease in the title, the number of authors, the number of patients, the citations according to Google Scholar, the journal impact factor, and the Altmetric score were retrieved. Google search trends for the terms "Kawasaki'' and "COVID,'' "COVID-19,'' and "coronavirus'' were also retrieved, as was the number of Reuters news articles published on the topic. These data were compared longitudinally on a weekly basis. The quality of the reporting of the study was evaluated using the STROBE guidelines for observational studies with more than three patients and using the CARE guidelines for case reports of three or fewer patients. Results: Eighty-six articles were included, among which ten were preprints (three of which were subsequently published) and 49 were clinical articles (57%). A total of 857 patients were described. The median number of authors per article was five (range, 1-45), the median number of patients was four (1-186), the median number of citations was one (0-170), the median Altmetric score was 12 (0-7242), and the median journal impact factor was 3.7 (1-74.7). For the clinica

摘要： BACKGROUND Hospital admissions and surgical operations commonly trigger anxiety in young children. Despite employing numerous support measures in our hospital, such as a pre-operative play room, the encouragement of parental companionship during induction of anaesthesia and distraction therapy, allaying the anxiety of our young surgical patients remains a challenge. OBJECTIVES To evaluate the effectiveness of a Home-Initiated-Programme-to-Prepare-for-Operation (HIPPO) on emotional manifestation and anxiety in children undergoing surgery. DESIGN, SETTING AND PATIENTS One hundred and thirty children were randomly assigned to either control or intervention group between February 2018 and April 2019 in a tertiary paediatric hospital in Singapore. INTERVENTION In addition to our standard pre-operative workflow, the intervention group received an additional home preparation kit consisting of an animated video on preoperative preparation and age-specific preoperative preparation activity sheets. MAIN OUTCOME MEASURES The primary outcome was the Children's Emotional Manifestation Scale score to evaluate behaviour and emotion in the children before and during induction of anaesthesia. Secondary outcomes evaluated anxiety levels in parents and children, the child's behaviour and degree of co-operation using the State-Trait Anxiety Inventory scores, State-Trait Anxiety Inventory Children scores, the Induction Compliance Checklist scores, the Visual Analogue Scale scores for anxiety and the feedback questionnaire. RESULTS The difference between the Children's Emotional Manifestation Scale score in control and intervention groups was not statistically significant. A promising difference was however observed in one of the secondary outcomes where the state-State-Trait Anxiety Inventory Children scores of 7 to 10-year olds in the intervention group almost reached significance;P = 0.067. CONCLUSION Despite being a child-friendly, easily accessible and affordable tool for patient ed

关键词： Uveal melanoma   Alternative splicing   Prognostic model   Bioinformatic analysis  

摘要： As a posttranscriptional regulatory mechanism, alternative splicing (AS) has the potential to generate a large amount of protein diversity from limited genes. The purpose of our study was to assess the usefulness of prognostic splicing events as novel diagnostic and therapeutic signatures for uveal melanoma (UM). The datasets, clinical traits and AS data of UM were obtained from The Cancer Genome Atlas (TCGA) database and TCGA SpliceSeq database. Using bioinformatics analysis, we identified 1047 AS events as candidate AS events closely related to prognosis from 920 parent genes. The gene enrichment analysis indicated that these genes were mainly enriched in cellular components (CC) including cytosol, nucleoplasm, cytoplasm and ribosome, and in molecular functions (MF), including protein binding and poly(A) RNA binding. Furthermore, we selected all survivalassociated splicing events to generate prognostic signatures, which included 4 exon skip (ES) events (DNASE1L1-90581-ES, NUDT1-78611-ES, BIN1-55198-ES, SEPN1-1195-ES) and 1 alternate promoter (AP) event (DPYSL2-83132-AP). The AS prognostic model was confirmed as independent overall survival (OS)-related factors (p = 0.014). A total of 17 splicing factors (SFs) involved in the regulation of AS were identified as related to the OS of UM patients. Our pooled data highlighted the usefulness and importance of AS biomarkers, which provided a potential strategy for the diagnosis and treatment of UM.

摘要： Public health concerns related to the COVID-19 pandemic are leading many residency and fellowship programs to transition from in-person to videoconference interviews (VCIs). The magnitude and speed of the shift to VCIs, the lack of existing research around bias and VCIs, and the underlying stress on all involved related to the pandemic put programs at risk of implementing virtual interviews without fully exploring their implications for diversity and equity. VCIs can promote diversity efforts by reducing the need for travel, making interviews more convenient and cost effective for applicants. However, VCIs may also introduce new biases and amplify existing biases in recruitment. VCIs introduce a dependence on technology to conduct the interview process, which may amplify systemic inequities in access to broadband internet and high-quality hardware. Communication delays due to technology challenges may negatively affect interview scores. Additionally, users experience increased cognitive load when participating in videoconferences, which can activate implicit biases. Exposure to cues in the interviewee's personal living situation previously unavailable to interviewers may lead to unconscious assumptions by interviewers, which may also influence scoring. Graduate medical education programs committed to maintaining equitable recruitment processes must be able to recognize potential biases in VCIs and implement strategies to mitigate them. This article identifies some of the biases VCIs can introduce to the recruitment process and offers strategies for programs to mitigate them. These include making interviewers aware of potential technology-based inequities, encouraging interviewers to minimize multitasking, and offering guidance on use of standardized backgrounds. The authors also recognize the limitations of offering behavioral strategies to mitigate systemic inequities and suggest that structural changes are needed to ensure equitable access to technology.

摘要： Objective Low- and middle-income countries account for over 90% of all road traffic injury deaths. Despite this, formal training in trauma management is not widely adopted in these countries. No specific training was available in prehospital or emergency department for life support before primary trauma care (PTC) course. This study was conducted to assess the effectiveness of the PTC course in the improvement of knowledge and skills of trauma management among participant in Pakistan. Method Two days of PTC courses were organised and conducted in various regions of Pakistan, participants per course comprising medical students, doctors, house officers, residents, and paramedics. The course comprises lectures of 5 hours and 30 minutes, skills workshops for 3 hours and discussion and multisystem trauma scenarios for 3 hours. Trauma management knowledge and clinical confidence of candidates were assessed using a predetermined multiple-choice questionnaire of 30 MCQs both at pre- and post-course, and using clinical scenarios, confidence matrix was assessed. Results A total 7852 of participants were trained, an average of 2 courses per month and 302 total courses. Mean score of pre-course MCQs was 60% and mean score of post-course MCQs was 82%. Among the participant postgraduate trainees, average in trauma knowledge and trauma clinical confidence were significantly higher in both pre- and post-course. The mean score of pre-course confidence matrix was 70% and the mean score of post-course confidence matrix was 93%;at the end of course, all participants showed a high level of confidence in managing trauma mock scenarios. A total of 5889 (75%) participants had a >= 78.5% post-workshop knowledge score. However, only 1963 (25%) participants had a trauma skill score with <= 75 marks. Conclusion PTC workshop could be an alternative and cost-effective flexible course for gaining knowledge and clinical skills of initial trauma management and strengthening the capacity of trauma m