关键词： 犊牛   牛喘病   治疗  

摘要： 伊通满族自治县地区肉牛养殖具有较长时间的养殖历史及丰富的养殖经验,对于犊牛牛喘病的防治,是伊通满族自治县地区犊牛养殖户急需解决的问题之一。只有在详细梳理犊牛牛喘病种类的基础上,将牛喘病与其他呼吸系统疾病区分开,提出科学的治疗方案,并且建立系统的防御牛喘病的措施,才能提高犊牛养殖的质量,打造优质的犊牛养殖品牌。

关键词： 缺血性卒中   贝叶综合征   危险因素   相关性研究  

摘要： 目的探讨急性缺血性脑卒中(AIS)新危险预警指标——贝叶综合征(Bayes综合征)的心电图表现及其与AIS其他危险因素的相关性。方法选择2018年10月至2019年6月甘肃省酒泉市人民医院收治的心电图为窦性心律的195例AIS患者为研究对象,其中心源性栓塞性卒中患者80例(栓塞性卒中组),非栓塞性卒中患者115例(非栓塞性卒中组),比较2组患者一般资料、AIS相关危险因素、美国国立卫生研究院卒中量表(NIHSS)评分及房间阻滞综合征(IAB)的发生情况。将存在IAB的98例患者分为不完全IAB(pIAB)组和高度IAB(aIAB)组,比较2组患者阵发性心房颤动(简称房颤)史、左心房内径及心源性栓塞性卒中发生情况。采用SPSS 22.0统计软件进行数据分析。根据数据类型分别采用t检验或χ^(2)检验。危险因素的判断采用多因素logistic回归分析。结果栓塞性卒中组中53例(66.2%)患者常规心电图存在IAB,IAB和已知的心源性卒中危险因素高血压、阵发性房颤史、左心房扩大在2组中差异均有统计学意义(均P<0.05);2组NIHSSP评分比较,差异有统计学意义(P<0.05),栓塞性卒中组卒中程度重。阵发性房颤史、左心房扩大、心源性栓塞性卒中在aIAB中有较高的检出率(均P<0.05)。结论Bayes综合征的心电图表现是AIS(尤其心源性栓塞性卒中)的新危险预测因素,心电图表现为aIAB时更有利于预测心源性栓塞性卒中的发生及提高左心房扩大、房颤等危险因素的检出率。因此,重视Bayes综合征的心电图表现对提高脑卒中筛查与防治效果有重要的临床意义。

关键词： 因声求义   明通假   通假字教学  

摘要： 通假是中国古书中比较常见的用字现象之一,明通假是阅读古文的基本功。某些古文篇目被选入中学语文教材,成为中学语文教学中的重点和难点,通假字作为文言文教学的重要内容,也是师生必须解决的问题。因声求义作为以声音为线索探求汉字本义的训诂方法,在清代逐渐走向系统化和理论化。因此将因声求义的方法引入到中学语文通假字教学当中既有利于加强学术研究和语文教学实践的互动关系,又可以帮助学生切实掌握通假原理、提升其文言素养。

关键词： 老师   视频显示   变换角度   师生互动   学的课堂   网友   期待  

摘要： 事件速递日前,一则老师为学生颁发"最具期待奖"的新闻引得网友点赞。据了解,在吉林某小学的课堂评奖中,老师特意给一名男生颁发"最具期待小明星奖"。虽然该男孩在上学期"表现平平",但老师却坚信他可以变得更好。视频显示,领奖时男孩流泪哽咽。得奖后,他坚定向老师保证"今后会变得更好",并赢得了全班的掌声。如此温馨的画面感动了一众网友,网友们纷纷表示:被暖哭了。

关键词： 数列   集合   不等式   解三角形   数学文化  

摘要： 数学知识之间的交汇是教学大纲的基本要求,更是高考命题的指导方针,是高考命题的热点之一.特别对于数列这一重点知识,以数列为背景,与其他相关知识,如集合、不等式等的交汇与综合非常常见.

关键词： autophagosome   chaperone   congenital hypothyroidism   functional rehabilitation   G-protein coupled receptor   thyrotropin receptor  

摘要： Background: Loss-of-function mutations of thyrotropin receptor (TSHR) are one of the main causes of congenital hypothyroidism. As for many disease-associated G-protein coupled receptors (GPCRs), these mutations often affect the correct trafficking and maturation of the receptor, thus impairing the expression on the cell surface. Several retained GPCR mutants are able to effectively bind their ligands and to transduce signals when they are forced to the cell surface by degradation inhibition or by treatment with chaperones. Despite the large number of well-characterized retained TSHR mutants, no attempts have been made for rescue. Further, little is known about TSHR degradation pathways. We hypothesize that, similar to other GPCRs, TSHR retained mutants may be at least partially functional if their maturation and membrane expression is facilitated by chaperones or degradation inhibitors. Methods: We performed in silico predictions of the functionality of known TSHR variants and compared the results with available in vitro data. Western blot, confocal microscopy, enzyme-linked immunosorbent assays, and dual luciferase assays were used to investigate the effects of degradation pathways inhibition and of chemical chaperone treatments on TSHR variants' maturation and functionality. Results: We found a high discordance rate between in silico predictions and in vitro data for retained TSHR variants, a fact indicative of a conserved potential to initiate signal transduction if these mutants were expressed on the cell surface. We show experimentally that some maturation defective TSHR mutants are able to effectively transduce Gs/cAMP signaling if their maturation and expression are enhanced by using chemical chaperones. Further, through the characterization of the intracellular retained p.N432D variant, we provide new insights on the TSHR degradation mechanism, as our results suggest that aggregation-prone mutant can be directed toward the autophagosomal pathway instead of t

摘要： Expression and activity of serum- and glucocorticoid-inducible kinase 1 (SGK1) are associated with many metabolic and inflammatory diseases. In this study, we report that SGK1 promotes alternative macrophage polarization and restrains inflammation in the infectious milieu of the gingiva. Inhibition of SGK1 expression or activity enhances characteristics of classically activated (M1) macrophages by directly activating the transcription of genes encoding iNOS, IL-12P40, TNF-alpha, and IL-6 and repressing IL-10 at message and protein levels. Moreover, SGK1 inhibition robustly reduces the expression of alternatively activated (M2) macrophage molecular markers, including arginase-1, Ym-1, Fizz1, and Mgl-1. These results were confirmed by multiple gain- and loss-of-function approaches, including small interfering RNA, a plasmid encoding SGK1, and LysM-Cre-mediated sgk1 gene knockout. Further mechanistic analysis showed that SGK1 deficiency decreases STAT3 but increases FoxO1 expression in macrophages under M2 or M1 macrophage-priming conditions, respectively. Combined with decreased FoxO1 phosphorylation and the subsequent suppressed cytoplasmic translocation observed, SGK1 deficiency robustly enhances FoxO1 activity and drives macrophage to preferential M1 phenotypes. Furthermore, FoxO1 inhibition abrogates M1 phenotypes, and STAT3 overexpression results in a significant increase of M2 phenotypes, indicating that both FoxO1 and STAT3 are involved in SGK1-mediated macrophage polarization. Additionally, SGK1 differentially regulates the expression of M1 and M2 molecular markers, including CD68 and F4/F80 and CD163 and CD206, respectively, and protects against Porphyromonas gingivalis-induced alveolar bone loss in a mouse model. Taken together, these results have demonstrated that SGK1 is critical for macrophage polarization and periodontal bone loss, and for the first time, to our knowledge, we elucidated a bifurcated signaling circuit by which SGK1 promotes alternative, w

关键词： 奖金分配   班组员工   班组管理   业务技能   班长  

摘要： 安徽某企业一车间一班班长刘东反映:他们班组员工经常与其他班组员工私下交流,如果交流的是如何提升业务技能无可厚非,可他们经常交流的是班长管理某人某事对不对?考核某人是否公平?甚至奖金分配情况也互相比较,很怕自己吃亏。刘东觉得,如果真有疑问,可以直接问他,他会给出答案,去别的班组反映情况,只能让别的班组员工看笑话。而他们班员工却认为,班组之间交流很正常,通过这样的交流可以发现班组管理上的问题.

关键词： 林业扦插育苗技术   育苗养护管理   育种技术  

摘要： 随着我国对林业经济发展的需要,各种速生林技术得到了充足的发展。通过进行扦插育苗技术的应用,可以有效林业的发展,促进育苗成活率的大幅度提升,这样能够有效实现林业的进步。本文首先针对林业扦插育苗技术的内容进行阐述,然后对林业扦插育苗养护管理工作中的重点内容进行分析,最后提出其他育种技术,包括容器育苗技术、苗木培育技术。旨在能够更好地实现科学化种植和管理,进而促进我国林业的快速发展。

关键词： 《昭明文选》   石濂大汕   中古时期   行旅   明清之际  

摘要： 早在中古时期,学者即已明辨“行”与“游”的差异,《昭明文选》别“行旅”“游览”为两类,有关前者之诗文记述多是现实,后者更关乎审美。明清之际奇僧石濂大汕(1633-1705)曾自绘三十余幅述其行迹的画像,刻印于所著《离六堂集》之前,中有“行脚”“遨游”二图,倘说较为写实的《行脚图》描画大汕有关“行”的经历和生活,那么《遨游图》则偏向于形上层面展现其“游”的精神。画中人物头面昂扬,道服锦绣,身背宝剑,精神状态与之前“行脚”“负薪”“供母”诸图中略觉偃蹇之貌迥异。