摘要： INTRODUCTION: The increasing liver-related mortality calls for hepatic surveillance programs. To design them, factors selectively increasing liver-related vs overall mortality need to be identified. METHODS: We analyzed mortality data from 467,558 individuals recruited by the community-based UK Biobank. The mean follow-up was 11.4 years. Results: While all assessed genetic factors associated with increased liver-specific mortality, only homozygous TM6SF2 mutation and SERPINA1 mutation conferred elevated overall mortality. Among the environmental factors, obesity and metabolic syndrome disproportionately contributed to liver-related deaths. Discussion: Our data demonstrate an interplay between genetics and environment and provide a basis for hepatic surveillance programs.

关键词： Optical and Electronic Materials   Characterization and Evaluation of Materials  

摘要： In this paper, three different samples of spinel carbon@Sb2SnS4 (C@S) sulphide were successfully synthesized via simple hydrothermal technique using L-cysteine (L-cyst.), thioacetic acid (TAA) and thioacetamide (TAM) compounds as sulphur sources. Physical and surface characterizations for the synthesized sulphide powders, including X-ray diffraction (XRD), field emission electron microscope (FE-SEM), energy dispersive spectroscopy (EDS) and XPS techniques were carried out. The XRD results confirmed the formation of ternary sulphide Sb2SnS4 in the spinel cubic phase associated with graphite and minor phases of binary sulphides. The microstructure investigation of carbon-coated Sb2SnS4/TAA (C@S/TAA) revealed two-dimensional thin sheets collected as bundles that correspond to ternary sulphide phase, while small bright grains are related to the binary sulphides and oxides. Moreover, the existence of Sb3+ and Sn4+ was confirmed from the XPS double peaks of Sb3d and Sn3d orbitals. Galvanostatic cycling of the assembled cells indicated that C@S/TAA anode delivered the maximum discharge capacity of about 880 mA g(-1), while the C@S/L-cyst. cell possessed the lowest discharge capacity of about 772 mAh g(-1). Finally, the cell with C@S/TAA anode displayed the highest diffusion coefficient of Li+ ions and best rate capability performance due to the unique two-dimensional thin sheets-like morphology of Sb2SnS4 hybridized with carbon nanoplates.

摘要： INTRODUCTION: Patients with immune-mediated inflammatory diseases such as inflammatory bowel disease (IBD) on immunosuppressive and biologic therapies were largely excluded from severe acute respiratory syndrome coronavirus-2 messenger RNA vaccine trials. METHODS: We evaluated adverse events (AE) after messenger RNA vaccination in 246 adults with IBD participating in a longitudinal vaccine registry. RESULTS: In general, AE frequency was similar to that reported in the general population. AEs were more common among younger patients and those with previous COVID-19. AEs were less common in individuals receiving advanced therapies with biologics or small-molecule inhibitors. DISCUSSION: Those with IBD and other immune-mediated inflammatory diseases can be reassured that the AE risk is likely not increased, and may be reduced, while on advanced therapies.

关键词： Polybrominated diphenyl ethers (PBDEs)   Decabromodiphenyl ethane (DBDPE)   House dust   Risk assessment   Hanoi urban area  

摘要： This study investigated the occurrence, distribution of several additive brominated flame retardants (BFRs) such as polybrominated diphenyl ethers (PBDEs) and some novel brominated flame retardants (NBFRs) in urban indoor dust collected from ten inner districts of Hanoi, Vietnam to assess the contamination status, emission sources, as well as their associated human exposure through indoor dust ingestion and health risks. Total concentrations of PBDEs and NBFRs in indoor dust samples ranged from 43 to 480 ng g(-1) (median 170 ng g(-1)) and from 56 to 2200 ng g(-1) (median 180 ng g(-1)), respectively. The most abundant PBDE congener in these dust samples was BDE-209 with concentrations ranging from 29 to 360 ng g(-1), accounting for 62.6-86.5% of total PBDE levels. Among the NBFRs analyzed, decabromodiphenyl ethane (DBDPE) was the predominant compound with a mean contribution of 98.6% total NBFR amounts. Significant concentrations of DBDPE were detected in all dust samples (median 180 ng g(-1), range 54-2200 ng g(-1)), due to DBDPE as a substitute for deca-BDE. Other NBFRs such as 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), pentabromoethylbenzene (PBEB) and 2,2',4,4',5,5'-hexabromobiphenyl (BB-153) were found at very low levels. Based on the measured BFR concentrations, daily intake doses (IDs) of PBDEs and NBFRs via dust ingestion at exposure scenarios using the median and 95(th) percentile levels for both adults and children were calculated for risk assessment. The results showed that the daily exposure doses via dust ingestion of all compounds, even in the high-exposure scenarios were also lower than their reference dose (RfD) values. The lifetime cancer risks (LTCR) were much lower than the threshold level (10(-6)), which indicated the acceptable health risks resulting from indoor BFRs exposure for urban residents in Hanoi.

关键词： LODDS   LNR   lymph node classification   colorectal cancer  

摘要： Simple Summary We compared the predictive and prognostic performance of different lymph node classification systems regarding overall survival in patients with colorectal cancer (CRC). Distinct lymph node ratio (LNR) and Log odds of positive lymph nodes (LODDS) classifications demonstrated prognostic superiority over the N category only in patients with Stage III CRC. Background: Lymph node ratio (LNR) and the Log odds of positive lymph nodes (LODDS) have been proposed as a new prognostic indicator in surgical oncology. Various studies have shown a superior discriminating power of LODDS over LNR and lymph node category (N) in diverse cancer entities, when examined as a continuous variable. However, for each of the classification systems various cut-off values have been defined, with the question of the most appropriate for patients with CRC still remaining open. The present study aimed to compare the predictive impact of different lymph node classification systems and to define the best cut-off values regarding accurate evaluation of overall survival in patients with resectable, non-metastatic colorectal cancer (CRC). Methods: CRC patients who underwent surgical resection from 1996 to 2018 were extracted from our medical data base. Cox proportional hazards regression models and C-statistics were performed to assess the discriminative power of 25 LNR and 26 LODDS classifications. Regression models were adjusted for age, sex, extent of the tumor, differentiation, tumor size and localization. Results: Our study group consisted of 654 consecutive patients with non-metastatic CRC. C-statistic revealed 2 LNR and 5 LODDS classifications that demonstrated superior prognostic performance in patients with UICC III CRC, compared to the N category. No clear advantage of one classification over another could be demonstrated in any other patient subgroup. Conclusions: Distinct LNR and LODDS classifications demonstrate a prognostic superiority over the N category only in patients

关键词： Rebuilding   Multispecies fisheries   Forgone yield   U   S   West Coast  

摘要： Rebuilding overfished stocks is central to fisheries policy, with the United States Magnuson-Stevens Act aligning with the United Nations Sustainable Development Goal 14.4 "to restore fish stocks in the shortest time feasible at least to levels that can produce maximum sustainable yield." In mixed stock fisheries, very low allowable catches for rebuilding stocks can lead to an inability to harvest abundant stocks. There are consequently trade-offs between the yield obtained during rebuilding and the rate of rebuilding. We retrospectively evaluate rebuilding plans in the US West Coast groundfish fishery to identify alternative harvest strategies that could have minimized adverse impacts to stakeholders while still achieving stock rebuilding targets. We use current assessments of 13 groundfish stocks to project spawning biomass and catch under various harvest policies. We estimate that an additional $886 million USD in ex-vessel revenue could have been obtained had an FMSY strategy permitting slower rebuilding rates been adopted. We also examined what catch limits would have been under a FMSY strategy using the information available at the time rebuilding plans were implemented. These alternative catch limits would have provided much greater fishing opportunity while still rebuilding the stocks. Our findings support those of the National Research Council, which in 2014 reported that rebuilding plans based on fishing mortality rates may be preferable to those focused on meeting strict rebuilding timelines.

摘要： BACKGROUND Decision-making deficits in airway emergencies have led to adverse patient outcomes. A cognitive aid would assist clinicians through critical decision-making steps, preventing key action omission. OBJECTIVE We aimed to investigate the effects of a visual airway cognitive aid on decision-making in a simulated airway emergency scenario. DESIGN Randomised controlled study. SETTING Single-institution, tertiary-level hospital in Toronto, Canada from September 2017 to March 2019. PARTICIPANTS Teams consisting of a participant anaesthesia resident, nurse and respiratory therapist were randomised to intervention (N = 20 teams) and control groups (N = 20 teams). INTERVENTION Participants in both groups received a 15-min didactic session on crisis resource management which included teamwork communication and the concepts of cognitive aids for the management of nonairway and airway critical events. Only participants in the intervention group were familiarised, oriented and instructed on a visual airway cognitive aid that was developed for this study. Within 1 to 4 weeks after the teaching session, teams were video-recorded managing a simulated 'cannot intubate-cannot oxygenate' scenario with the aid displayed in the simulation centre. MAIN OUTCOME MEASURES Decision-making time to perform a front-of-neck access (FONA), airway checklist actions, teamwork performances and a postscenario questionnaire. RESULTS Both groups performed similar key airway actions;however, the intervention group took a shorter decision-making time than the control group to perform a FONA after a last action [mean +/- SD, 80.9 +/- 54.5 vs. 122.2 +/- 55.7 s;difference (95% CI) -41.2 (-76.5 to -6.0) s, P = 0.023]. Furthermore, the intervention group used the aid more than the control group (63.0 vs. 28.1%, P < 0.001). Total time of scenario completion, action checklist and teamwork performances scores were similar between groups. CONCLUSIONS Prior exposure and teaching of a visual airway cogniti

摘要： Biologic aortic valves are constructed with 3 stents corresponding to the commissures, which sit in the aortic root. When implanted using interrupted sutures, these stents may make the valve difficult to tie down safely in patients with small, calcified aortic roots. We present an easily reproducible technique to make this valve tie down safer. (C) 2021 by The Society of Thoracic Surgeons

摘要： During autophagy, proteins of the ATG8 family are conjugated to phosphatidylethanolamine (PE) in double-membrane structures called phagophores. Now, Durgan et al. have found that, during the non-canonical process of conjugating ATG8 proteins to single-membrane structures, ATG8 can be ligated to phosphatidylserine. Here, I discuss the potential consequences of their findings.

关键词： Hazards  

摘要： Models for estimating earthquake ground motions are a key component in seismic hazard analysis. In data-rich regions, these models are mostly empirical, relying on the ever-increasing ground-motion databases. However, in areas in which strong-motion data are scarce, other approaches for ground-motion estimates are sought, including, but not limited to, the use of simulations to replace empirical data. In Israel, despite a clear seismic hazard posed by the active plate boundary on its eastern border, the instrumental record is sparse and poor, leading to the use of global models for hazard estimation in the building code and all other engineering applications. In this study, we develop a suite of alternative ground-motion models for Israel, based on an empirical database from Israel as well as on four data-calibrated synthetic databases. Two host models are used to constrain model behavior, such that the epistemic uncertainty is captured and characterized. Despite the lack of empirical data at large magnitudes and short distances, constraints based on the host models or on the physical grounds provided by simulations ensure these models are appropriate for engineering applications. The models presented herein are cast in terms of the Fourier amplitude spectra, which is a linear, physical representation of ground motions. The models are suitable for shallow crustal earthquakes;they include an estimate of the median and the aleatory variability, and are applicable in the magnitude range of 38 and distance range of 1-300 km.