关键词： 考古所   遗迹遗物   等级秩序   民俗文化   考古学   城市规划   经典传承   碰撞交融  

摘要： 在《考古所见的北京历史文化特点》一文中,笔者梳理归纳了北京考古发现所反映的十项历史文化特点,包括1.谱系序列绵延久长,2.文化因素多元交错,3.遗迹遗物种类多,4.民族关系碰撞交融,5.异国交往源远流长,6.宗教信仰众教并存,7.皇家特色引人瞩目,8.等级秩序尊卑有别,9.民俗文化多层多元,10.城市规划经典传承。

关键词： 核仁小RNA   肿瘤   分子标志物   非编码RNA  

摘要： 核仁小RNA(snoRNA)是非编码RNA(ncRNA)中的一类,主要参与核糖体RNA转录过程的修饰。snoRNA是某些微小RNA的前体,也可由长链非编码RNA进一步加工而来;此外,snoRNA也是参与细胞各种生理和病理过程的重要调控分子。snoRNA与肿瘤及其他多种疾病的发生、发展、预后不良息息相关,甚至可以作为潜在的治疗靶点。该文就snoRNA的基础结构、生物学功能、检测方法、相关数据库,以及snoRNA在肿瘤及其他多种疾病中的研究进展进行综述。

关键词： 技术   重新想象   艺术实践  

摘要： 技术生活在今天已经全面渗透进我们的日常生活,并反过来塑造着我们生活的内容和方式。这样的现实是我们每个人都要承担的,无法逃避。我们必须要重新去想象技术,才有可能积极地参与到对技术生活的改造中。而我们对技术生活的重新想象,受制于我们的对它的依赖。许多行动者便把目光投向了艺术实践,这不无道理。因为当代艺术对系统的扰乱与篡改,早已成为其内在逻辑的一部分,这提供了对技术现实改造的各种可能性。

关键词： 市政工程   工程建设其他费用   因素  

摘要： 工程建设其他费用是工程建设投资的重要组成部分,文中对市政工程概算中部分工程建设其他费用计列需考虑的因素做了简要分析。

关键词： Cultured meat   Plant based meat   Meat alternatives   Consumer behaviour   Consumer attitudes  

摘要： Alternatives to conventional meat are considered an increasingly important tool in the drive to reduce consumption of animal products for environmental, public health and ethical reasons. We present two waves of a cross-sectional survey from a nationally representative sample in Belgium in 2019 (n = 1001) and 2020 (n = 1000). Participants answered questions online about their diets, attitudes towards existing plant-based meat alternatives, and attitudes towards cultured meat (grown from animal cells). We find that the proportion of Belgian consumers who said existing plant-based meat alternatives met their needs increased significantly from 44% in 2019 to 51% in 2020. We also find a significant increase in concern for issues related to animal agriculture, in particular the environment. We found no significant change in attitudes towards cultured meat between the two waves;in both 2019 and 2020, 39.3% of Belgian consumers said they would buy cultured meat. Regression analyses revealed that plant-based alternatives were more appealing to women and those with vegetarian diets, whilst cultured meat was more appealing to men. Overall, just 11.2% of consumers are both unsatisfied with existing meat alternatives and unwilling to buy cultured meat, while 43.2% of respondents were positive towards either plant-based or cultured meat, but not both, highlighting the need for a variety of alternative proteins in the market. Both cultured meat and plant-based meat were more appealing to younger consumers and those in the northern, predominantly Dutch-speaking region of Flanders. We discuss the implications of these findings for researchers and those seeking to strategically displace demand for animal products.

关键词： 清代   蝗灾   虫害  

摘要： 蝗灾与水旱灾害并称为我国历史上的三大灾害,蝗灾常与旱灾伴随发生,蝗虫迁飞,入田食禾,以致赤地千里,民不聊生。本文通过全面梳理《清实录》及地方志相关记载,以州县为单位统计蝗灾发生次数,分别以朝年、季节及省区为纲目整合数据,力图呈现有清一代飞蝗为灾的总体状况。蝗灾以外,清代另有见于史书记载的由昆虫造成的灾害50余种,其中螟虫、黏虫、黑虫等11种虫害相对较为常见且危害较大,本文另将清代见诸实录、方志记载的11种其他虫害发生状况分别列表分析附后。

关键词： alternative splicing events   network   progression-free survival-related model   testicular germ cell tumor  

摘要： Accumulating evidence supports the significance of aberrant alternative splicing(AS)events in cancer;however,genome-wide profiling of progression-free survival(PFS)-related AS events in testicular germ cell tumors(TGCT)has not been ***,we analyzed high-throughput RNA-sequencing data and percent-spliced-in values for 150 patients with *** univariate and multivariate Cox regression analysis and a least absolute shrinkage and selection operator method,we identified the top 15 AS events most closely associated with disease progression.A risk-associated AS score(ASS)for the 15 AS events was calculated for each ***,pathological stage,and T stage were significantly associated with disease progression by univariate analysis,but only ASS and pathological stage remained significant by multivariate *** ability of these variables to predict 5-year progression was assessed using receiver operating characteristic curve *** had stronger predictive value than a combination of age,pathological stage,and T stage(area under the curve=0.899 and 0.715,respectively).Furthermore,Kaplan—Meier analysis of patients with low and high ASS demonstrated that high ASS was associated with significantly worse PFS than low ASS(P=1.46 × 10^(-7)).We also analyzed the biological functions of the PFS-related AS-related genes and found enrichment in pathways associated with DNA repair and ***,we identified a regulatory network of splicing factors with expression levels that correlated significantly with AS events in ***,this study identifies a novel method for risk stratification of patients and provides insight into the molecular events underlying TGCT.

关键词： 数字信息资源保存   法律关系   知识产权  

摘要： 在数字信息资源长期保存的过程中,相关法律在调整其社会关系时所形成的权利和义务关系就是数字信息资源长期保存法律关系,这一法律关系是调整性的法律关系。文章明晰了数字信息资源长期保存法律关系中的相关主体,即呈缴者、保存者、管理者、使用者,分析了数字信息资源长期保存法律关系的特征,并探讨了数字信息资源长期保存中保存者与其他三类主体之间的法律关系。

关键词： Asian population   porous polyethylene implant   saddle nose   septal reconstruction  

摘要： Background: Congenital or secondary deficiency in septal cartilage leads to an unpleasant cosmetic appearance and compromised function as well. Rhinoplasty maneuvers such as spreader graft and septal extension graft with autologous tissue have been exhibited to correct the deformities. However, the relatively severe donor site morbidity stands as a main concern for both surgeons and patients. Methods: From January of 2014 to April of 2018, 52 patients presenting septal deformities underwent rhinoplasty with our modified technique. A piece of Medpor (8438) was tailored, folded and then placed as a combination of spreader and septal extension graft. The surgical outcomes were evaluated both objectively and subjectively. Results: All the patients were followed up for 12 to 24 months postoperatively. The ratio of tip projection and the nasal length exhibited significant improvement in all our patients. Nasal obstruction subjectively mended among the 24 patients who had airway obstruction complaint preoperatively. Only 2 patients had severe adverse events and the implants were removed instantly. Conclusions: With our modified technique, Medpor proved to be an effective and reliable material for the reconstruction of septal cartilage, which provides us an alternative way to achieve extended spreader and septal extension graft with one single implant in the correction of saddle nose.