关键词： 石黑一雄   克拉拉   好客   恐惧  

摘要： 克拉拉对于人类他者具有一种近似无限的好客精神,这主要表现在她对乔西高度的责任心和爱心以及与之紧密关联的伟大的奉献、牺牲精神,同时她还对人类具有博大、深沉的情怀;不过这种好客、友爱的基础部分可能是源于克拉拉对于人类的恐惧与怀疑,同时她的好客是以乔西为中心,有差异序列的,且克拉拉偶尔也会表现出一点自私。不过总体上,克拉拉对他者的付出远远超出了人类对她的态度,这恐怕是未来高度智能时代到来后值得人类反思的一个问题。

关键词： 纪念性建筑   石碑   巨石阵   威尔士   纪念物   英国  

摘要： 一项新研究表明,英国巨石阵中的一些大石碑可能来自另一个在更早期建造的环形巨石纪念性建筑-瓦恩曼石圈。瓦恩曼石圈是英国最古老的石圈之一,它的周围有一个人口密集的威尔士人居住点。但到了公元前3000年前后,可能有一些威尔士,人在迁居他乡时把圈中一些石碑也带去了,因为这些石碑很可能是他们祖先身份的纪念物。

关键词： Stomach adenocarcinoma   Alternative splicing   Tumor microenvironment   Immune-related genes and pathways  

摘要： BACKGROUND Alternative splicing(AS)increases the diversity of mRNA during transcription;it might play a role in alteration of the immune microenvironment,which could influence the development of immunotherapeutic strategies against *** To obtain the transcriptomic and clinical features and AS events in stomach adenocarcinoma(STAD)from the *** overall survival data associated with AS events were used to construct a signature prognostic model for *** Differentially expressed immune-related genes were identified between subtypes on the basis of the prognostic *** STAD,2042 overall-survival-related AS events were significantly enriched in various pathways and influenced several cellular ***,the network of splicing factors and overallsurvival-associated AS events indicated potential regulatory mechanisms underlying the AS events in *** An eleven-AS-signature prognostic model(CD44|14986|ES,PPHLN1|21214|AT,RASSF4|11351|ES,KIAA1147|82046|AP,PPP2R5D|76200|ES,LOH12CR1|20507|ES,CDKN3|27569|AP,UBA52|48486|AD,CADPS|65499|AT,SRSF7|53276|RI,and WEE1|14328|AP)was constructed and significantly related to STAD overall survival,immune cells,and cancer-related *** differentially expressed immune-related genes between the high-and low-risk score groups were significantly enriched in cancer-related *** This study provided an AS-related prognostic model,potential mechanisms for AS,and alterations in the immune microenvironment(immune cells,genes,and pathways)for future research in STAD.

关键词： 公司增资   出资义务   利益衡量   资本充实责任  

摘要： 当前司法实践对于公司增资时,若增资股东未尽出资义务,其他股东是否应当如设立时的发起人一样承担连带责任存在分歧。本文通过考察公司设立时发起人承担资本充实责任的法理基础、发展趋势,结合利益衡量法以及对富有争议的裁判依据《关于股东因公司设立后的增资瑕疵应否对公司债权人承担责任的复函》进行形式与实质符合性检验,尚不能得出增资时其他股东承担连带责任的规范意旨。因此,否定增资股东未尽出资义务时其他股东的民事责任不仅于"理由"层面具有充分的法理支撑,而且于"结果"层面使类案具有了统一的裁判尺度。

关键词： 药学信息学   氯雷他定   过敏性鼻炎   疗效   Meta分析  

摘要： 目的:系统评价氯雷他定联合其他西药治疗过敏性鼻炎的有效性与安全性,以指导临床用药。方法:计算机检索CNKI、万方、维普数据库,纳入比较氯雷他定联合其他西药(试验组)与氯雷他定单独使用(对照组)治疗过敏性鼻炎的随机对照试验(RCT),检索时间从2016年1月至2021年2月。结果:纳入了15篇RCT,共1950例患者,包括试验组976例,对照组974例。Meta分析结果显示:试验组与对照组在有效率方面有显著性差异(P<0.05);在不良情况发生方面情况相当,差异无统计学意义。结论:氯雷他定联用西药可有效治疗过敏性鼻炎,效果优于单独使用氯雷他定,但研究结果证据强度受纳入文献质量所限,需更多高质量RCT证实。

关键词： 定语后置   宾语前置   宾语前置句   复习法  

摘要： 文言文因表达习惯和表强调等需要,出现了与现代汉语不同的句式,理解和掌握特殊的文言句式,有助于正确理解文言文内容。同时,文言句式也是高考考查的内容之一,是翻译题的重要赋分点。文言特殊句式包括:判断句、被动句、倒装句、省略句、固定句式。其中,倒装句中的宾语前置句、定语后置句是难点。运用四步学习法,可以点燃我们的学习宾语前置句、定语后置句的热情,收到事半功倍之效。

关键词： 上海鲁迅纪念馆   文学导报   许广平   萌芽月刊   国民党当局   机关刊物   左联   油印本  

摘要： "左联"成立后第3年,鲁迅收到油印本《秘书处消息》第一期,这是鲁迅参编的《萌芽月刊》(《新地月刊》)、《前哨》(《文学导报》)以及其他"左联"机关刊物被国民党当局查封后,所出版的新一种"左联"机关刊物。目前《秘书处消息》只见第一期,也未见它出版之前的其他类似的、油印的"左联"机关刊物。上海鲁迅纪念馆所藏的这本《秘书处消息》第一期,是1950年代由鲁迅夫人许广平捐赠的。对于《秘书处消息》第一期的介绍.

关键词： 西夏文   世俗文献   通假字  

摘要： 学者研究已经证实西夏文佛典文献中存在通假现象。通过调查可知,西夏文世俗文献中也有通假字,分布于民间文书、夏译汉籍、国家法典等,使用较为频繁。辨析西夏文通假字,对于重新审视、考证世俗文献释读过程中存疑的词义具有重要意义。

摘要： IMPORTANT SAFETY INFORMATION AND INDICATIONSCONTRAINDICATIONS:• EYLEA is contraindicated in patients with ocular or periocular infections, active intraocular inflammation, or known hypersensitivity to aflibercept or to any of the excipients in *** AND PRECAUTIONS:• Intravitreal injections, including those with EYLEA, have been associated with endophthalmitis and retinal detachments. Proper aseptic injection technique must always be used when administering EYLEA. Patients should be instructed to report any symptoms suggestive of endophthalmitis or retinal detachment without delay and should be managed appropriately. Intraocular inflammation has been reported with the use of EYLEA.• Acute increases in intraocular pressure have been seen within 60 minutes of intravitreal injection, including with EYLEA. Sustained increases in intraocular pressure have also been reported after repeated intravitreal dosing with VEGF inhibitors. Intraocular pressure and the perfusion of the optic nerve head should be monitored and managed appropriately.• There is a potential risk of arterial thromboembolic events (ATEs) following intravitreal use of VEGF inhibitors, including EYLEA. ATEs are defined as nonfatal stroke, nonfatal myocardial infarction, or vascular death (including deaths of unknown cause). The incidence of reported thromboembolic events in wet AMD studies during the first year was 1.8% (32 out of 1824) in the combined group of patients treated with EYLEA compared with 1.5% (9 out of 595) in patients treated with ranibizumab;through 96 weeks, the incidence was 3.3% (60 out of 1824) in the EYLEA group compared with 3.2% (19 out of 595) in the ranibizumab group. The incidence in the DME studies from baseline to week 52 was 3.3% (19 out of 578) in the combined group of patients treated with EYLEA compared with 2.8% (8 out of 287) in the control group;from baseline to week 100, the incidence was 6.4% (37 out of 578) in the combined group of patients treated with EYLEA

关键词： 艾滋病患者   样本来源   防治目标   HIV/AIDS   医疗机构   科室分布   治疗率   报卡  

摘要： 2014年,联合国艾滋病规划署(UNAIDS)提出了“三个90%”的防治目标,2016年国办印发《中国遏制与防治艾滋病“十三五”行动计划》将其作为工作目标之一,即到2020年,人类免疫缺陷病毒感染者和艾滋病患者(HIV/AIDS)的发现率、治疗率、治疗成功率均达到90%。我国新发现HIV/AIDS的主要途径是医疗机构,本研究对样本来源为其他就诊者检测病例的报卡科室分布进行了回顾性调查,分析HIV/AIDS病例首次就医的临床科室分布,从而为最大限度发现病例提供依据。