关键词： 医学检验   通识教育   满意度  

摘要： 调查在医学检验专业教育中学生对通识教育的满意度了解情况,以促进本专业通识教育的持续性改进。结合文献及学生访谈对问卷进行设计,采用“问卷星”进行线上匿名问卷调查。李克特五点量表分析学生对通识教育的满意度和了解情况,χ^(2)检验进行不同专业组间的比较,SPSSAU(Version 20.0)对数据进行统计分析及可视化。本次调查共回收有效问卷209份,研究数据信度质量高且具有效度。90.00%的学生表示喜欢通识类课程,检验专业学生喜欢的通识类课程为“科学探索与生命教育”,与非检验专业学生喜欢的通识类课程有差异。学生对通识类课程的接受度较高,喜欢通识类课程的学习。但对通识教育的不了解仍然是影响满意度的主要原因,同时,由于医学类专业本身课业的繁重,对专业知识无帮助成为影响学生不喜欢通识类课程的主要原因。现阶段,该校所开设通识类课程已获得学生的普遍认可。增强学生对通识教育的了解程度,增设融合专业课程体系的通识类课程可提高通识教育的满意度。

摘要： Background and AimsNose surgical procedures are associated with moderate postoperative pain, being the first 24 hours the most intense pain period. A lower level of postoperative pain promotes better healing, decreases anxiety and increases patient’s comfort. Multimodal analgesia approach should be applied in order to provide maximum comfort while avoiding opioids adverse effects such as postoperative nausea and vomiting (PONV). PONV risk is exacerbated due to a passive blood flow that reaches the stomach during procedure.2 We report a case of an infrazygomatic maxillary nerve block (IZMNB) as part of multimodal analgesia for rhinoplasty *** intend to increase awareness to IZMNB as an effective analgesic technique for maxillofacial *** report and literature *** 28-year-old patient, ASA II, was admitted for a rhinoplasty and mentoplasty. Under general anesthesia, an ultrasound-guided IZMNB was performed bilaterally with ropivacaine 0.1%, 5cc each side, as part of a multimodal analgesic technique. Paracetamol and cetorolac were also administered. After emergence, patient referred low level of pain, needing only 2 mg of morphine at the post-anesthetic care unit, due to chin pain (glossopharyngeal nerve area).Abstract 19 Figure 1Abstract 19 Figure 2ConclusionsIZMNB mechanism of action relies on local anesthetic dispersion within the pterygopalatine fossa. The maxillary nerve block (second branch of the trigeminal nerve), at pterygopalatine fossa level, promotes effective analgesia to the middle third of the face.

关键词： 世界女排联赛   二传   传球组织效果   比较分析  

摘要： 排球运动作为技能主导类隔网对抗性项目,近年来比赛场上的节奏变化越来越快,排球比赛的观赏性也得到了较大提升,受到了人们的关注。现如今,球员身高优势越来越明显,网上高度的竞争也就越来越受到重视,导致对二传的培养更加困难。作为团队的灵魂,二传负责着球队的进攻和对对方进攻的有利反击,二传的竞技水平往往决定了整个球队的战术水平。该文运用文献资料法、视频观察法、数据统计法及对比分析法,以2019年世界女排联赛为例,细致分析了中国女排与其他四强队伍二传手传球组织效果的差别。

摘要： 准备写这篇文章时,我正在加州肆虐的疫情中焦急地等待着归期,心绪也随疫情起起伏伏.当初离开时,疫情还没有在全球蔓延开来,没想到一年之久,世界已变了模样.这魔幻的一年,仿佛被病毒浓缩成了一个事件,时间已经不存在了."

关键词： 清火片   造假   显微红外光谱法   ICP-OES   TLC   HPLC-DAD   UHPLC-MS/MS  

摘要： 目的采用显微红外光谱法联合其他手段揭示6批问题清火片的造假本质。方法显微红外光谱法分析大量不明矿物碎块,配合总灰分、酸不溶性灰分检查,并通过ICP-OES法测定铝含量,TLC、HPLC-DAD、UHPLC-MS/MS法鉴定有机染料。结果6批样品非法添加了硅酸盐类化合物和有机染料亮蓝,铝含量在296.38~2135.78 mg/kg范围内。结论多种分析手段的配合可全面、准确、有效地剖析问题清火片,从而为客观真实评价药品质量和加强药品监管提供支撑与依据。

关键词： antiretroviral   chemical exchange saturation transfer   HIV-1   lamivudine   theranostics  

摘要： Objective: Antiretroviral drug theranostics facilitates the monitoring of biodistribution and efficacy of therapies designed to target HIV type-1 (HIV-1) reservoirs. To this end, we have now deployed intrinsic drug chemical exchange saturation transfer (CEST) contrasts to detect antiretroviral drugs within the central nervous system (CNS). Design and methods: CEST effects for lamivudine (3TC) and emtricitabine (FTC) were measured by asymmetric magnetization transfer ratio analyses. The biodistribution of 3TC in different brain sub-regions of C57BL/6 mice treated with lipopolysaccharides was determined using MRI. CEST effects of 3TC protons were quantitated by Lorentzian fitting analysis. 3TC levels in plasma and brain regions were measured using ultraperformance liquid chromatography tandem mass spectrometry to affirm the CEST test results. Results: CEST effects of the hydroxyl and amino protons in 3TC and FTC linearly correlated to drug concentrations. 3TC was successfully detected in vivo in brain sub-regions by MRI. The imaging results were validated by measurements of CNS drug concentrations. Conclusion: CEST contrasts can be used to detect antiretroviral drugs using MRI. Such detection can be used to assess spatial--temporal drug biodistribution. This is most notable within the CNS where drug biodistribution may be more limited with the final goal of better understanding antiretroviral drug-associated efficacy and potential toxicity.

关键词： adolescents   Africa   biomarkers   HIV   lung disease   pathogenesis  

摘要： Objective: HIV-associated chronic lung disease (HCLD) is a common comorbidity in children and adolescents in sub-Saharan Africa (SSA). The pathogenesis of HCLD is unclear and may be driven by underlying dysregulated systemic immune activation and inflammation. We investigated the association between 26 plasma soluble biomarkers and HCLD. Design: Case--control analysis of baseline biomarker data from 336 children and adolescents (6-19 years old) with perinatal HIV infection (PHIV) and HCLD (cases) and 74 age-matched and sex-matched controls with PHIV but no CLD. HCLD was defined as having a forced expiratory volume in one second (FEV1) z score less than -1 with no reversibility. Methods: Cryopreserved plasma collected at recruitment was used in a multiplex bead assay (Luminex) to measure baseline levels of soluble biomarkers. Logistic regression alongside data-reduction and techniques quantifying the interconnectedness of biomarkers were used to identify biomarkers associated with odds of HCLD. Results: Biomarkers of general immune activation and inflammation (beta 2M, CRP, sCCL5, GCSF, IFN-gamma, IP-10), T-cell activation (sCD25, sCD27), platelet activation (sCD40-L), monocyte activation (sCD14), coagulation (D-Dimer), cellular adhesion (E-selectin), and extracellular matrix degradation (MMP-1, MMP-7, MMP-10) were associated with increased odds of HCLD. Exploratory PCA and assessment of biomarker interconnectedness identified T-cell and platelet activation as centrally important to this association. Conclusion: HCLD was associated with a large number of soluble biomarkers representing a range of different pathways. Our findings suggest a prominent role for T-cell and platelet activation in HCLD.