关键词： 综合实践   学科   整合  

摘要： 虽然综合实践活动课程与各学科课程有着本质的区别,但是,综合实践活动的研究主题可以在其他学科课程中产生,而其他学科课程知识又可以在综合实践活动中得到延伸、重组和提升。因此,在实践中,教师应正确处理综合实践活动课与各学科之间的关联,将它们整合起来。这已成为今后教育发展的趋势。综合实践活动课不仅可以激发学生的学习兴趣,提高学生的学科知识水平和能力,还能使学生情智得到全面而健康的发展。

摘要： Purpose/Objective(s) The RO-APM will trial an episode-based payment schema over a five-year period starting in 2022. Practices were randomly selected for mandatory inclusion in the RO-APM. Participating departments have different case mixes, patients, and clinical practices that will dictate the relative impact of the RO-APM. It is our aim to create a highly versatile Monte Carlo model to simulate RO-APM effects on reimbursement and practice financial stability. In this study, we specifically focus on suburban and rural settings. Materials/Methods Monte Carlo simulations were developed in Python to model the effects of the RO-APM model over the 5-year trial period. The model requires a patient population, distribution of delivery techniques, and fractionation patterns per delivery technique for each of the 16 defined disease sites. This information was gathered from two non-associated regional clinics: one that serves primarily a suburban population (SP) while the other serves a mixed SP and rural population (MP). All fixed and variable financial expenses were collected and included. The inclusion of extra administrative work for the RO-APM submission was also included using time-driven activity-based costing methods. Considering each clinic's Medicare population, statistical analyses of how the patient population, delivery technique, and fractionation patterns impact reimbursement for this subset population was performed. The RO-APM model was also compared to the fee-for-service model (FFS-M). Results Disease site distributions were within 7.5% absolute difference between the two clinics. The four most common disease sites treated averaged between the two clinics were lung (20.1%), breast (16.9%), prostate (12.6%), and head & neck (H&N) (9.9%). Fractionation patterns were within 3 fractions (fx) across all disease site modalities except for bladder (MP +19fx) and lung (MP +13fx) IMRT, and 3D H&N (MP +3.4fx). Medicare population was 30% and 33% for the SP and MP, re

摘要： Purpose/Objective(s) The COVID19 pandemic required radiation oncologists (ROs) to consider shorter treatment courses to minimize patient and staff exposure and conserve healthcare resources. Hematologic ROs adopted hypofractionated radiation therapy (hRT) regimens according to guidelines published by the International Lymphoma Radiation Oncology Group (ILROG). We report for the first time the preliminary efficacy and toxicity of these novel hypofractionated regimens in the treatment of hematologic malignancies. Materials/Methods We conducted a multicenter, multinational retrospective study under the direction of the ILROG. All patients receiving hRT according to ILROG guidelines from 1/1/2020 to 8/31/2020 were included. Patient and treatment details were abstracted from separate institutional databases. Toxicity was graded using CTCAE v5.0. Results Ninety-three patients from 4 institutions treated with 114 RT courses were included. Patient and treatment details are displayed in Table 1. Median follow up for the cohort was 179 days, and 77 patients (82%) were alive at last follow up. Maximal toxicity experienced by patients included Grade 1 (n = 16), Grade 2 (n = 1) and Grade 3 (n = 1) toxicities. Of 80 sites with response assessment within the RT field, 69% of patients achieved a complete response (n = 55), 20% partial response (n = 16), 9% stable disease (n = 7), and 2% progressive disease (n = 2). No COVID19 infections during or after RT have been documented in this patient cohort. Conclusion HRT according to ILROG guidelines resulted in low rates of acute toxicity and reasonable short-term treatment efficacy. Longer follow up and comparison with control groups is needed to draw more definitive conclusions and will be presented at the Annual Meeting.

关键词： 刨花板   不确定性   人造板行业   可预见   现代化   人造板生产线  

摘要： 全球新冠疫情大流行带来了混乱和不确定性,2020年将成为人造板行业下降最多的年份之一。在2020年初新冠病毒出现之前,被订购的新人造板生产线的数量已经有所下降,而且这种趋势看起来还会持续更长的时间。就刨花板而言,明确会上马的项目,在我们可预见的未来会减少。目前的工作重点是工厂的现代化和生产线的改造,以便提高工厂效率。

关键词： 微透析   活体取样   药学   其他领域   应用进展  

摘要： 微透析作为一门新兴的生物活体采样技术,具有活体连续取样、动态观察、定量分析、采样量小、组织损伤轻等优点。目前微透析技术多用于药学领域的药动学(PK)和药动学-药效学(PK-PD)研究方向,其可以直接有效地监测靶组织中内源性或外源性药物动态变化。本文对微透析技术在药学及其他领域中的应用和发展现状进行综述,以更全面的了解该技术。

关键词： 二传   北体女排   组织进攻  

摘要： 在当今世界排球比赛中,对抗性越来越强,二传是比赛中的灵魂,技战术水平主要取决于其竞技能力。本文以北体女排与前四强其他队伍二传传球组织进攻效果为研究对象,通过文献资料法、录像统计法、数据统计法以及对比分析法。研究表明:北体女排与前四强其他队伍二传相比,身高、体重、年龄相差不大,但网上高度占据一定优势。在组织进攻上,北体一传环节较稳定,二传垫调球较少,二传的进攻欲望较强,二次球能力突出。北体女排在3号位以及2号位区域组织进攻多,二传与队员默契程度很高,在组织战术方面比较灵活。女排与前四强其他队伍二传运动员相比,北体女排的反击一对一拦网较多,说明二传的传球组织能力有一定效果,防守反击质量较高,单人拦网的数据优于其他3名队伍。

关键词： 免疫治疗   免疫相关性胰腺炎   糖皮质激素   不良事件  

摘要： 目的探究免疫相关不良事件的临床特征及可能的机制。方法回顾性分析1例以腹痛为主要表现免疫相关胰腺炎患者的临床特征,检索国内外相关文献对免疫治疗后不良事件进行文献复习。结果根据患者临床表现及辅助检查,诊断为免疫相关性胰腺炎,予糖皮质激素冲击治疗并随诊观察,患者的临床症状及体征明显改善,无复发倾向。结论免疫相关性胰腺炎是罕见的免疫治疗不良事件,临床决策需积极评估免疫治疗的获益及风险。

关键词： Fillers   Mastic   Asphalt mixture   Flexible pavement   Jarosite (JS)   Industrial waste   Recycling  

摘要： Jarosite (JS) is an industrial solid waste obtained from zinc industries that plays an important role as a pollutant engendering soil and ground water contamination. The present research article has highlighted the use of JS as a filler material in pavement construction, thereby limiting its pernicious threat to the environment and promoting sustainable construction practices. This study compared the performance of asphalt mastics and mixes made with JS with their counterparts made with conventional materials (stone dust) and a widely used waste (fly ash) filler. A physical and chemical characterization of fillers was completed, and then the asphalt concrete mixes were designed at varied filler proportions (2%, 4%, 6%, and 8%). Subsequently, the asphalt mastics corresponding to various mixes were designed, and their rheological and morphological properties were assessed. Finally, the performance of asphalt mixes against various types of distress was analyzed along with their environmental suitability. The results highlighted that asphalt mixes containing JS exhibited paramount resistance against cracking, moisture sensitivity, and rutting. This result was mostly attributed to the high porosity, finer nature, high specific surface area, and high asphalt-filler interaction of JS. In addition to the superior engineering properties, the asphalt mixes containing JS were also found to exhibit satisfactory environmental suitability.

关键词： PM2.5   灰色关联度   攀枝花  

摘要： 为了研究攀枝花市PM2.5质量浓度变化特征及影响因素,根据2014-2019年攀枝花市环境空气质量数据,文章采用灰色关联分析法研究了PM2.5与其他环境空气质量参数之间的关系。结果表明,24小时内,在上下班高峰期,PM2.5浓度较大;PM2.5浓度在12月、11月、1月较高;攀枝花市近五年来PM2.5浓度表现为缓慢上升趋势,2019年略有下降;PM2.5季节变化特征,冬季浓度明显高于夏季。运用灰色关联度模型对空气质量各因素(PM2.5、SO_(2)、NO_(2)、CO、O_(3)-8、PM10)进行关联度计算,结果显示,PM10对PM2.5影响最大,SO_(2)、NO^(2)、CO与PM2.5均属于高关联,且与PM10、SO_(2)、NO_(2)、CO均呈正相关,与O_(3)-8呈负相关;攀枝花市PM2.5/PM10比值在0.5以上,PM2.5已成为攀枝花市主要污染物,且主要是受工业生产、汽车尾气排放及城市发展建设等的综合影响。