关键词： belatacept   graft versus host disease   GvHD  

摘要： Background Immunosuppressive prophylaxis is usually given to decrease the development of acute graft versus host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (HSCT). Belatacept is a Cytotoxic T-lymphocyte-associated protein 4, blocking agent, an immunosuppressive agent used for organ rejection prevention in adult renal transplant recipients. Methods We describe two children in whom belatacept was successfully used for GvHD prophylaxis. Case 1 was noncompliant with prior immunosuppressive therapy for aplastic anemia, and Case 2 developed severe thrombotic microangiopathy (TMA) precluding the use of calcineurin inhibitors (CNI) or mTOR inhibitors. Results and Conclusion Belatacept was found to be a safe alternative in preventing GvHD in 2 patients in whom traditional prophylactic therapies were not possible to use.

关键词： quantitative trait loci   alternative polyadenylation   complex traits   human diseases  

摘要： Alternative polyadenylation (APA)associated genetic variants have been proposed to impact diverse human phenotypes and disorders. In a recent study, Li et al. established a landscape of 3'-untranslated region (UTR) APA quantitative trait loci (3'aQTLs) across multiple human tissues, revealing substantial 3'aQTLs that contribute to complex human traits and diseases.

关键词： Cerebrospinal fluid   Blood-brain barrier   Gadolinium-based contrast media   Tear   Anterior chamber   Posterior chamber  

摘要： Cerebral ischemia results in disruption of the blood-brain barrier (BBB) allowing leakage of gadolinium-based contrast media (GBCM) into cerebrospinal fluid (CSF) within the craniospinal and perineural subarachnoid spaces (SAS). This phenomenon is well visualized with fluid-attenuated inversion recovery MRI techniques and allows for visualization of CSF flow dynamics. We present a case of ischemia-induced BBB disruption resulting in accumulation of GBCM in the SAS and ocular chambers as well as within the precorneal tear film and nasolacrimal duct. We present imaging evidence for a hypothetical alternate CSF absorption pathway through the ocular structures in keeping with prior experimental evidence.

关键词： Bakery products   Response surface methodology   Carbohydrates   Fibers   Glycemic index  

摘要： The optimum formulation of a low carb pound cake was determined using alternative ingredients to replace the main sources of digestible carbohydrates in the standard formulation. Surface response methodology was a useful tool in the investigation of the use of custard apple puree (CAP), fructooligosaccharides (FOS) and soy protein hydrolysate (SPH) as partial or total replacers for wheat flour, sucrose, and powdered whole milk, respectively. The quality of pound cakes was assessed by measuring the batter and cake properties. The percentage of ingredients substitution affected the specific gravity of the batter, cakes specific volume, crumb firmness, instrumental color parameters (L*, a*, b*) and number and circularity of alveoli from pound cake slices. The model equations developed can be used for predicting the quality of the pound cake. The optimum formulation of low carb pound cake with 40.98% of CAP, 94.94% of FOS and 100% of SPH, in replacement of wheat flour, sucrose and powdered whole milk, respectively, has a 93.70% of desirability. A reduction of 60.67% in digestible carbohydrates was reached. The main reduction occurs in the starch content due to the wheat flour replacement and the non-reducing sugar content due to the sucrose partial substitution. The low carb pound cake had a moderate glycemic index (60.08%), a low glycemic load (4.69%) and accepted by the judges through sensory analysis, with an acceptability index of 72.08 +/- 3.97%.

关键词： Tornadogenesis   Supercells   Tornadoes   Vorticity  

摘要： Fine-resolution computer models of supercell storms generate realistic tornadic vortices. Like real tornadoes, the origins of these virtual vortices are mysterious. To diagnose the origin of a tornado, typically a near-ground material circuit is drawn around it. This circuit is then traced back in time using backward trajectories. The rate of change of the circulation around the circuit is equal to the total force circulation. This circulation theorem is used to deduce the origins of the tornado's large vorticity. However, there is a well-known problem with this approach;with staggered grids, parcel trajectories become uncertain as they dip into the layer next to the ground where horizontal wind cannot be interpolated. To circumvent this dilemma, we obtain a generalized circulation theorem that pertains to any circuit. We apply this theorem either to moving circuits that are constrained to simple surfaces or to a "hybrid" circuit defined next. Let A be the horizontal surface at one grid spacing off the ground. Above A the circuit moves as a material circuit. Horizontal curve segments that move in A with the horizontal wind replace segments of the material circuit that dip below A. The circulation equation for the modified circuit includes the force circulation of the inertial force that is required to keep the curve segments horizontal. This term is easily evaluated on A. Use of planar or circular circuits facilitates explanation of some simple flows. The hybrid-circuit method significantly improves the accuracy of the circulation budget in an idealized supercell simulation.

关键词： Antimicrobial resistance   Anti-virulence therapy   Gram-positive bacteria   Sortase A inhibitors   Virulence factors  

摘要： Virulence factor, sortase A (SrtA), has crucial roles in the pathogenesis of Gram-positive superbugs. SrtA is a bacterial cell membrane enzyme that anchors crucial virulence factors to the cell wall surface of Gram-positive bacteria. SrtA is not necessary for bacterial growth and viability and is conveniently accessible in the cell membrane;therefore, it is an ideal target for antivirulence drug development. In this review, we focus on antimicrobial resistance (AMR)-expressing bacteria and SrtA as a potential target for overcoming AMR. The mechanism of action of SrtA and its inhibition by various types of inhibitors, such as synthetic small molecules, peptides, and natural products, are provided. Future SrtA research perspectives for alternative drug development to antibiotics are also proposed.

关键词： Chandrasekhar's H-function   Legendre polynomials  

摘要： In this paper, a new approach using shifted Legendre polynomials has been applied for the numerical solution of the nonlinear integral equation for the Chandrasekhar H-function for isotropic scattering. This new analytical approach with its easily executable equations brought the nonlinear equation to a numerically computable form. Our numerical results show good agreement with those reported in existing literature with a difference between 0.0 0 09 % and 0.11 %. (c) 2021 Elsevier Ltd. All rights reserved.