关键词： Vertical femoral neck fractures   Medial buttress sliding plate   Femoral neck system   Biomechanics  

摘要： Background: No consensus has been reached for the treatment of vertical femoral neck fractures (vFNFs). Recently, two alternative methods were invented to treat vFNFs, one of which is a new plate with a sliding groove, which was designed as a substitution of the medial buttress locking plate to combine with cannulated compression screws (CCS) for reducing the breakage possibility of the proximal locking screw during the bone healing. Another one is the femoral neck system (FNS), which was believed with biomechanical superiority. This study aims to compare the biomechanics of these two new implants with three previous methods via finite element analysis (FEA) to validate whether they are suitable for the treatment of vFNFs. Methods: Five 70-degree Pauwels type III transcervical FNFs (vFNFs, AO/OTA 31B2.3(r)) models were built and fixed by CCS augmented with the newly designed sliding groove buttress plate (CCS+BS) and FNS. For comparison, models fixed by three parallel cannulated compression screws (CCS), biplane double-supported screw fixation (BDSF), CCS augmented with a medial buttress locking plate (CCS+BL) were also built. A 2100N load was applied along with the mechanical axis. Parameters of the maximal stress as well as the maximal displacement of the implants and bone, the maximal relative displacement of interfragments, and the stiffness, were analyzed to compare the biomechanical characteristics of the five models. Results: CCS+BS and CCS+BL showed stronger fixation strength with improved stiffness (1012.05N/mm, 1092.04N/mm), reduced maximal displacement of the implants (1.976mm, 1.838mm) and bone (2.075mm, 1.923mm), when compared with CCS (925.11N/mm, 2.158mm and 2.270mm) and BDSF (842.36N/mm, 2.299mm and 2.493mm). While FNS showed the weakest stiffness (593.22N/mm) and largest maximal displacement of the implants (3.234mm) and bone (3.540mm) among the five models. Conclusions: CCS+BS has a better biomechanical performance than CCS and BDSF, which offers a

关键词： bread wheat   TaGS3   alternative splicing   grain weight   grain size  

摘要： The heterotrimeric G-protein mediates growth and development by perceiving and transmitting signals in multiple organisms. Alternative splicing (AS), a vital process for regulating gene expression at the post-transcriptional level, plays a significant role in plant adaptation and evolution. Here, we identified five splicing variants of G(gamma) subunit gene TaGS3 (TaGS3.1 to TaGS3.5), which showed expression divergence during wheat polyploidization, and differential function in grain weight and size determination. TaGS3.1 overexpression significantly reduced grain weight by 5.89% and grain length by 5.04%, while TaGS3.2-3.4 overexpression did not significantly alter grain size compared to wild type. Overexpressing TaGS3.5 significantly increased the grain weight by 5.70% and grain length by 4.30%. Biochemical assays revealed that TaGS3 isoforms (TaGS3.1-3.4) with an intact OSR domain interact with WGB1 to form active G(beta gamma) heterodimers that further interact with WGA1 to form inactive G(alpha beta gamma) heterotrimers. Truncated isoforms TaGS3.2-3.4 , which lack the C-terminal Cys-rich region but have enhanced binding affinity to WGB1, antagonistically compete with TaGS3.1 to bind WGB1, while TaGS3.5 with an incomplete OSR domain does not interact with WGB1. Taking these observations together, we proposed that TaGS3 differentially regulates grain size via AS, providing a strategy by which the grain size is fine-tuned and regulated at the post-transcriptional level.

关键词： Complementary and alternative medicine   Documentation concordance   Electronic medical record   Integrative medicine   Medical education   Patient-provider communication  

摘要： Background and purpose: Over half of patients utilize complementary and alternative medicine (CAM), yet fewer than 10 % of physicians inquire about use. This prospective cohort study sought to increase patient-provider communication about CAM through electronic medical record (EMR) prompts and education, as well as study concordance rates of physician and nursing CAM-related documentation. Materials and methods: Recordings in history and physical (H&P) documents authored by first-year pediatric residents were used as a proxy for communication. Rates of documentation were assessed at baseline, after the introduction of an EMR prompt, and after an educational intervention. Nursing documentation was compared with resident documents to assess rates of concordance regarding CAM-related documentation. Results: Baseline CAM-related documentation rate was 24 % and increased to 50 % after introducing an EMR CAM prompt (p < 0.001). No significant change occurred after education: 38 % had CAM-related documentation (p = 0.09). Physician and nursing documentation concordance rates were 58 % at baseline, 48 % after introduction of prompts, and 35 % after introducing education. Conclusion: Visual cues alone may be effective in increasing patient-provider communication about CAM, though low concordance between physician and nursing documentation may suggest variability in how CAM is defined and inquired about.

关键词： Input–   output tables   Regional modelling   CHARM   Inter-regional trade flows  

摘要： The main scope of the paper is to review the construction method of (multi-)regional input-output tables (RIOTs) in the Czech Republic at the NUTS 3 regional level. We compare the estimation of regional IO tables based on a modified cross-hauling adjusted regionalisation method (CHARM) applied by the authors with application of the hybrid approach of (Sixta and Vltavska in Stat Stat Econ J 97:4-14, 2017) from the Department of Statistics at the University of Economics in Prague. The aim of the presented paper is to contribute to the discussion about the suitability of alternative methodological approaches from the perspective of quality and time. We assume that despite the lack of official, published RIOTs by state statistical offices, the existing methodology of the relatively simpler non-survey CHARM method represents an adequate option for the generation of regional input-output tables suitable for further analytical research.

关键词： erythropoietin   myelodysplastic syndromes   transfusion  

关键词： Cultivation in the tropics   Dormex (R)   earlier production   Prunus persica  

摘要： Peach trees initiate flowering and then dense budding when the temperatures in winter are steadily low. When temperatures during the winter are high or when the chilling accumulation needs of the cultivar are not met, it is necessary to apply chemicals that stimulate flowering and budding in a uniform manner. This study aimed to evaluate alternative products for breaking the dormancy of 'Kampai' peach trees in a subtropical region. The experiment was conducted with 'Kampai' peach trees in the 2018, 2019 and 2020 production with the following treatments: (1) negative control composed only of water (control);(2) positive control composed of hydrogen cyanamide at a dose of 13% (commercial product Dormex (R)) plus 4.5% mineral oil;(3) Erger G (R) organomineral fertilizer supplemented with calcium nitrate at a dose of 3%;(4) potassium nitrate at a dose of 5%;and (5) copper sulphate at a dose of 0.3%. We evaluated affected budding capacity, flowering, the production cycle, peach production, the quality of peach trees and the enzymatic activities of catalase and guaiacol peroxidase. Hydrogen cyanamide and the organomineral fertilizer Erger G (R) promoted earlier flowering and an earlier production cycle. On the other hand, hydrogen cyanamide and copper sulphate stimulated flower opening and peach production. The chemicals used decreased catalase activity (24 h after application) and increased guaiacol peroxidase activity (6 h after application). The application of copper sulphate may be an option to break the dormancy of peach trees in the subtropics.

关键词： Diffusion   Equivalent contaminated layer   Landfill   Diffusivity coefficient  

摘要： Landfills have been extensively used as waste deposits in most of the big cities in the world. Therefore, considerably large urban areas have contamination threats. Engineering solutions applied to prevent or contain soil, and water contamination often involve the application of liners, which are low permeability barriers made of materials such as compacted clay and geomembranes. In many liner applications, once reduced rates of seepage are expected, diffusion has proved to be relevant, if not dominant, to the process of contaminant transport. Normally, diffusivity parameters can be assessed by a single-reservoir pure diffusion test, where a contaminant solution is placed above a saturated soil sample and the solution's concentration is monitored over time. Once the temporal variation of concentration is measured, the process of back-calculating diffusivity parameters is not standardized. In this paper, an analytical model of the diffusive transport of contaminants is revisited considering the initial and boundary conditions of the pure diffusion test. In this model, the contaminant solution reservoir is included in the analysis domain as an equivalent contaminated soil layer. The analytical solution relies on a series evaluation, which may be a drawback to everyday engineering situations. Therefore, we build a high-accuracy exponential approximation to the solution. Expedited evaluation procedures are proposed to provide reasonable estimates for the fitting parameters. Also, in order to illustrate the applicability of the new solution, test datasets of a soil around the Jockey Club Landfill (JCL) site, one of the major landfills in Latin America, have been modeled. We discuss possible issues of considering linear isotherms to model the sorption characteristics of soils, indicating that convex isotherms, if linearly modeled, may lead to overestimated values of the diffusivity parameter.

关键词： covid-19   pediatric inflammatory multisystem syndrome   severe acute respiratory syndrome   obesity   sars-cov-2  

摘要： OBJECTIVES: To describe the demographics, clinical characteristics, and hospital course among persons <21 years of age with a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated death. METHODS: We conducted a retrospective case series of suspected SARS-CoV-2-associated deaths in the United States in persons <21 years of age during February 12 to July 31, 2020. All states and territories were invited to participate. We abstracted demographic and clinical data, including laboratory and treatment details, from medical records. RESULTS: We included 112 SARS-CoV-2-associated deaths from 25 participating jurisdictions. The median age was 17 years (IQR 8.5-19 years). Most decedents were male (71, 63%), 31 (28%) were Black (non-Hispanic) persons, and 52 (46%) were Hispanic persons. Ninety-six decedents (86%) had at least 1 underlying condition;obesity (42%), asthma (29%), and developmental disorders (22%) were most commonly documented. Among 69 hospitalized decedents, common complications included mechanical ventilation (75%) and acute respiratory failure (82%). The sixteen (14%) decedents who met multisystem inflammatory syndrome in children (MIS-C) criteria were similar in age, sex, and race and/ or ethnicity to decedents without MIS-C;11 of 16 (69%) had at least 1 underlying condition. CONCLUSIONS: SARS-CoV-2-associated deaths among persons <21 years of age occurred predominantly among Black (non-Hispanic) and Hispanic persons, male patients, and older adolescents. The most commonly reported underlying conditions were obesity, asthma, and developmental disorders. Decedents with coronavirus disease 2019 were more likely than those with MIS-C to have underlying medical conditions.

ISBN: (纸本)9787567237292