关键词： 《决议》   自我革命   战略思想   新征程   基本遵循   坚持自我   六中全会   重大成就  

摘要： 党的十九届六中全会审议通过的《中共中央关于党的百年奋斗重大成就和历史经验的决议》(以下简称《决议》),全面总结了中国共产党百年奋斗的重大成就和历史经验,为中国共产党团结带领全国各族人民在全面建设社会主义现代化国家新征程上,齐心协力实现中华民族伟大复兴中国梦的宏伟目标,提供了基本遵循。《决议》科学总结了中国共产党坚持自我革命的光荣传统和宝贵经验,鲜明贯穿了党的初心使命主线,突出阐述了坚持自我革命、以伟大自我革命引领伟大社会革命,以伟大社会革命促进伟大自我革命的战略思想,对于在过去一百年赢得伟大胜利和荣光的中国共产党和中国人民,在新时代新征程上赢得更加伟大的胜利和荣光,具有深远的历史意义、理论意义和现实意义。

关键词： Adalimumab   Ankylosing spondylitis   anti-Tumor necrosis factor   Rheumatic disease   Spondyloarthritis   Supplements   Anti-inflammatory diet   Dietary changes  

摘要： Background and purpose: Current treatment strategies for ankylosing spondylitis (AS) include adalimumab and other biological drugs. However, treatment failures and side effects are commonly observed. This report documents the successful use of supplements and dietary changes to treat a patient with AS after cessation of adalimumab therapy. Patient presentation: A 38-year-old human leukocyte antigen B27 positive female patient with AS showed no improvement when treated with a non-steroidal anti-inflammatory drug. The patient then began adalimumab therapy with some success;however, after nine months, she developed a disseminated and refractory Molluscum contagiosum infection. Adalimumab was withdrawn, and the patient started taking supplements, while adopting an anti-inflammatory diet (dairy-free, gluten-free, and sugar-free). Normalization of inflammatory markers was achieved after two months, and magnetic resonance imaging of the sacroiliac revealed a notable physical improvement.

关键词： Pre-exposure prophylaxis (PrEP)   PrEP navigation   Transgender   trans women   Gender non-binary persons   Gender queer persons   Men who have sex with men (MSM)  

摘要： Strategies to reduce new HIV infections include pre-exposure prophylaxis (PrEP). Of the estimated over 221,000 Californians with an indication for PrEP, only 31,280 (14 %) were currently taking the medication as of 2019. Centers for Disease Control and Prevention Project PrIDE funds were used to support and develop California PrEP navigation programs designed to increase PrEP uptake among trans persons and men who have sex with men (MSM). An analysis of PrIDE-funded PrEP navigation service outcomes was conducted to highlight where continuum drop-off occurred and how it varied among priority populations. Quantitative service delivery data for PrEP navigation program activities conducted from October 1, 2015 to September 30, 2018 were collected across three county-level local health jurisdictions (LHJs) via standardized, agency-completed service delivery data collection tools. Analyses included frequencies and crosstabs. These variations were not tested statistically but highlight group-specific needs to be addressed before implementing PrEP navigation within California. Continued systematic collection and analyses of PrEP continuum outcomes will allow programs to dynamically identify and address barriers to PrEP uptake in priority populations.

关键词： glucagon‐   like peptide‐   1 receptor   high‐   throughput screening   nonpeptide agonist   positive allosteric modulator   type 2 diabetes   β   ‐   cell  

摘要： Glucagon-like peptide-1 (GLP-1) receptors belong to the pharmaceutically important Class B family of GPCRs and are involved in many biologically significant signalling pathways. Its incretin peptide ligand GLP-1 analogues are effective treatments for Type 2 diabetes. Although developing non-peptide low MW drugs targeting GLP-1 receptors remains elusive, considerable progress has been made in discovering non-peptide agonists and positive allosteric modulators (PAMs) of GLP-1 receptors with demonstrated efficacy. Many of these compounds induce biased signalling in GLP-1 receptor-mediated functional pathways. High-quality structures of GLP-1 receptors in both inactive and active states have been reported, revealing detailed molecular interactions between GLP-1 receptors and non-peptide agonists or PAMs. These progresses raise the exciting possibility of developing non-peptide drugs of GLP-1 receptors as alternative treatments for Type 2 diabetes. The insight into the interactions between the receptor and the non-peptide ligand is also useful for developing non-peptide ligands targeting other Class B GPCRs.

关键词： paediatric alternative payment models   paediatric value-based payment   social drivers  

摘要： Purpose of review The aim of this study was to summarize emerging elements of paediatric alternative payment models (APMs), identify strategies to address barriers in implementing paediatric APMs and share policy approaches. Recent findings The unique health needs of children and adolescents must be considered as paediatric value-based care and APMs are developed. The longer time period for achieving cost savings, relatively few existing model tests and challenges with cross-sector data-sharing and pooled financing are barriers to the adoption of paediatric APMs. The Integrated Care for Kids (InCK) model and some state-based efforts are testing whether an integrated service delivery model combined with paediatric APMs can reduce expenditures and improve care and outcomes. However, the relative paucity of models makes it difficult to identify the most effective strategies and overall impact of paediatric APMs. Emerging paediatric APMs include the following key elements: developmentally appropriate approaches, paediatric-specific quality and cost measures, a focus on primary care, special considerations for children with complex healthcare needs and cross-sector integration of data, workforce and financing. A variety of strategies, rooted in cross-sector partnerships, can be pursued to address implementation barriers and ultimately support paediatric care transformation.

关键词： Pyrolysis   Plastic oil   Nanoparticle   Performance   Emission  

摘要： This work presents the feasibility study of utilizing neat plastic oil TiO2 nanoparticle is added as additive in the proportion of 100, 150, and 200 ppm fuelled in a stationary single cylinder diesel engine to asses the performance, emission and combustion characteristics. From the local municipality, the waste plastic bottles are collected and it it fed into the pyrolysis reactor to convert into pyrolysis oil. The results from performance analysis revealed that the enrichment of neat plastic with TiO2 nanoparticle enhanced the brake thermal efficiency than without any additives in the raw oil (plastic oil). Similarly, the results of emission revealed that smoke, and hydrocarbon are considerably reduced with increased proportion of nano additive. Results also revealed that the formation of NOx is higher with POAL200 than plastic oil and other concentration of TiO2 nanoparticle and diesel fuel. This is due to the higher availability of oxygen content in the fuel, higher quality of fuel and reduced ignition delay.

关键词： Complement system   alternative pathway   COVID-19   SARS-CoV-2   immunology   hemostasis  

摘要： Background: Severe coronavirus disease 2019 (COVID-19) is characterized by impaired type I interferon activity and a state of hyperinflammation leading to acute respiratory distress syndrome. The complement system has recently emerged as a key player in triggering and maintaining the inflammatory state, but the role of this molecular cascade in severe COVID-19 is still poorly characterized. Objective: We aimed at assessing the contribution of complement pathways at both the protein and transcriptomic levels. Methods: To this end, we systematically assessed the RNA levels of 28 complement genes in the circulating whole blood of patients with COVID-19 and healthy controls, including genes of the alternative pathway, for which data remain scarce. Results: We found differential expression of genes involved in the complement system, yet with various expression patterns: whereas patients displaying moderate disease had elevated expression of classical pathway genes, severe disease was associated with increased lectin and alternative pathway activation, which correlated with inflammation and coagulopathy markers. Additionally, properdin, a pivotal positive regulator of the alternative pathway, showed high RNA expression but was found at low protein concentrations in patients with a severe and critical disease, suggesting its deposition at the sites of complement activation. Notably, low properdin levels were significantly associated with the use of mechanical ventilation (area under the curve = 0.82;P = .002). Conclusion: This study sheds light on the role of the alternative pathway in severe COVID-19 and provides additional rationale for the testing of drugs inhibiting the alternative pathway of the complement system.

关键词： Richter syndrome   chronic lymphocytic leukemia   NF-kappa B  

摘要： Simple Summary: The transformation process of chronic lymphocytic leukemia into an aggressive lymphoma, called Richter syndrome (RS), is incompletely understood, and therapeutic options are limited. Here, we report CARD9 to be expressed in a subset of RS tissue specimen and in the first and only available RS cell line, U-RT1. In U-RT1, CARD9 attaches to BCL10 and MALT1, and knockdown of CARD9 leads to a significant reduction in cell viability. We hypothesized that CARD9 plays an oncogenic role in RS through the activation of NF-kappa B signaling. Our findings may help to extend the current knowledge about the pathogenesis of RS and promote the development of targeted therapies for this aggressive *** syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, mostly diffuse large B-cell lymphoma (DLBCL). Despite intensive therapy, patients with RS have an unfavorable clinical outcome. The detailed pathobiology of Richter transformation still needs to be elucidated. Here, we report high mRNA and protein levels of CARD9 in the RS cell line U-RT1. Co-immunoprecipitation revealed the assembly of a CBM complex using CARD9 instead of CARD11. CARD9 is known to be an activator of NF-kB signaling in myeloid cells. U-RT1 Western blot analyses showed phosphorylation of I kappa B as well as IKK, indicating a constitutively active canonical NF-kB pathway. This was further supported by the significant reduction in cell viability and CYLD cleavage products after CARD9 siRNA knockdown. We also showed immunostaining for CARD9 in 53% of cases analyzed in a series of RS tissue specimens, whereas other lymphomas rarely show CARD9 expression. This is the first report on ectopic expression and function of CARD9 in an aggressive B-cell lymphoma. Our findings suggest that CARD9 may contribute to the pathogenesis of RS.

关键词： thermal spraying   ferrochromium slag   high temperature   TBC   dry sliding wear  

摘要： The aim of this study is to show that ferrochrome (FeCr) slag, an industrial waste material, can be used as an alternative protective coating material in service conditions for the caster roll surfaces used in the continuous casting line of steelmaking. Atmospheric plasma spray (APS) method was utilized in coating processes. Considering the working conditions of continuous casting production line, the Thermal Barrier Coating (TBC) system was used as a basis for deposition processes. For production of the TBC system, the commercial NiCoCrAlY (Amdry, 45 + 5 mu m) coating powder was initially deposited as metallic bond coat layer onto the surface of AISI 316L substrate, and then FeCr slag layer was successfully deposited as the top coating layer. After the deposition of FeCr slag powder, the resulting coating layer was found to have low porosity with a homogeneous microstructure. Dry sliding wear tests were performed under different loads (7N, 10N and 13N) and temperatures (200, 400 and 600 degrees C) using a ball-on-disc test rig with heating unit. At low loads (7N, 10N) and temperatures (200, 400 degrees C), predominantly spallation type abrasion was observed, while at high load and temperatures (13N, 600 degrees C), the formation of tribolayer and delamination were the dominant wear mechanisms on the surface of FeCr slag coatings. According to the test results, it can be said that FeCr slag powder is a suitable candidate as a protective coating material against adhesive wear at elevated temperatures for caster rolls.

关键词： MIS-C   COVID-19   Three-dimensional echocardiography   Ventricular systolic-diastolic function  

摘要： Cardiac involvement is a common and serious problem in multisystem inflammatory syndrome in children (MIS-C). Echocardiographic evaluation of systolic and diastolic function by traditional, tissue Doppler and three-dimensional (3D) echocardiography was performed in consecutive 50 MIS-C patients during hospitalization and age-matched 40 healthy controls. On the day of worst left ventricular (LV) systolic function (echo-1), all left and right ventricular systolic function parameters were significantly lower (p < 0.001), E/A ratio was significantly lower, and averaged E/e ' ratio was significantly higher (median 1.5 vs. 1.8, p < 0.05;8.9 vs. 6.3, p < 0.001 respectively) in patients compared to control. Patients were divided into 2 groups according to 3D LV ejection fraction (LVEF) on the echo-1: Group 1;LVEF < 55%, 26 patients, and group 2;LVEF >= 55%, 24 patients. E/e ' ratio was significantly higher in group 1 than group 2 and control at discharge (median 7.4 vs. 6.9, p = 0.005;7.4 vs. 6.3, p < 0.001 respectively). Coronary ectasia was detected in 2 patients (z score: 2.53, 2.6 in the right coronary artery), and resolved at discharge. Compared with group 2, group 1 had significantly higher troponin-I (median 658 vs. 65 ng/L;p < 0.001), NT-pro BNP (median 14,233 vs. 1824 ng/L;p = 0.001), procalcitonin (median 10.9 vs. 2.1 mu g/L;p = 0.009), ferritin (median 1234 vs. 308 mu g/L;p = 0.003). The most common findings were ventricular systolic dysfunction recovering during hospitalization, and persisting LV diastolic dysfunction in the reduced LVEF group at discharge. Coronary artery involvement was rare in the acute phase of the disease. Also, in MIS-C patients, the correlation between LV systolic dysfunction and markers of inflammation and cardiac biomarkers should be considered.