关键词： Audi   奥迪   繁华都市  

摘要： 奥迪跨界好物出新,Audi quattro sneaker现已为阁下升级至更炫、更酷、更具科技感的2.0版本。夜幕降临,繁华都市点点霓虹悬空亮起。抬脚轻按鞋底外侧的quattro按钮,这颗红色标识与后跟的奥迪四环便会透出幽亮红光,后掌两侧的三角元素矩阵也会同点亮。

关键词： 郑板桥   早期   异体字   六分半书  

摘要： 本文通过对郑板桥早期作品用字特点的分析,揭示了郑氏早年隐而未发的“求变、求异”的倾向与动机,以异体字的使用为抓手,阐析了郑氏前、后期创作理路中存在的一贯性线索。

关键词： 统计监督   监督体系   党内监督   贯通协调  

摘要： 统计监督是新时代党和国家监督体系的重要组成部分,强化统计监督与其他监督的贯通协同能够有效推进国家治理体系和治理能力现代化。党的十八大以来,党和国家监督实现了体系化的创新发展,统计监督的内涵和层次得到拓展,有力推动了国家治理的法制化、透明化和责任化。统计监督与其他监督的贯通协同必须坚持党内监督的主导地位,建立与党委工作部门的合作机制,强化与其他监督的内容贯通、形式对接、信息共享,完善统计违纪违法案件移交机制。增强统计监督与其他监督的协调性,可从加强党的全面领导、增强法律法规衔接、完善监督方式方法、运用大数据和区块链技术等方面采取针对性对策措施。

关键词： 人类身体   技术客体   人机结合   行为重建   表演转向  

摘要： “身体”作为一个理论概念的崛起,寄托了人文主义者对“表演”的精神乌托邦诉求。这也可以被看作是应对科学光芒的照耀和技术的入侵所带来的对人类认知世界中处于中心地位的、现代性意义上的人类“精神”的挑战。在一种“后人类”状态中,机器人、人工智能、区块链等技术造物与人类“身体”之间发生新的关系可能性,这为艺术家创作表演作品打开了新的空间,而曾经被科学祛魅的“灵性”的世界也可能以数字艺术的方式复归。

摘要： Purpose: Loss of TGF beta signaling increases error-prone alternative end-joining (alt-EJ) DNA repair. We previously translated this mechanistic relationship as TGF beta and alt-EJ gene expression signatures, which we showed are anticorrelated across cancer types. A score representing anticorrelation, beta Alt, predicts patient outcome in response to genotoxic therapy. Here we sought to verify this biology in live specimens and additional datasets. Experimental Design: Human head and neck squamous carcinoma (HNSC) explants were treated in vitro to test whether the signatures report TGF beta signaling, indicated by SMAD2 phosphorylation, and unrepaired DNA damage, indicated by persistent 53BP1 foci after irradiation or olaparib. A custom NanoString assay was implemented to analyze the signatures' expression in explants. Each signature gene was then weighted by its association with functional responses to define a modified score, beta Alt(w), that was retested for association with response to genotoxic therapies in independent datasets. Results: Most genes in each signature were positively correlated with the expected biological response in tumor explants. Anticorrelation of TGF beta and alt-EJ signatures measured by NanoString was confirmed in explants. beta Alt(w) was significantly (P < 0.001) better than beta Alt in predicting overall survival in response to genotoxic therapy in The Cancer Genome Atlas (TCGA) pancancer patients and in independent HNSC and ovarian cancer patient datasets. Conclusions: Association of the TGF beta and alt-EJ signatures with their biological response validates TGF beta competency as a key mediator of DNA repair that can be readily assayed by gene expression. The predictive value of beta Alt(w) supports its development to assist in clinical decision making.

关键词： 社会经济发展   地球生物   加拿大一枝黄花   外来生物   本土植物   生态系统   外来物种   营养物质  

摘要： 自然界中的物种总是处在不断迁移、扩散的动态中。而人类的活动又进一步加剧了物种的扩散,使得许多生物得以突破地理隔绝,拓展至其他环境当中。这些扩散到新环境的物种称为“外来物种”。一些外来生物的入侵会对原有的生态系统和社会经济发展造成威胁,如著名的“加拿大一枝黄花”,繁殖能力超强,与本土植物争夺营养物质和水分,“我花开处百花杀”,被称为“生态杀手”。

关键词： Coronavirus disease 2019 (COVID-19)   Multisystem inflammatory syndrome in children (MIS-C)   Two-dimensional speckle tracking echocardiography (2D-STE)   Longitudinal strain   Circumferential strain  

摘要： Multisystem inflammatory syndrome in children (MIS-C) is one of the most significant sequela of coronavirus disease 2019 (COVID-19) in children. Emerging literature has described myocardial dysfunction in MIS-C patients using traditional and two-dimensional speckle tracking echocardiography in the acute phase. However, data regarding persistence of subclinical myocardial injury after recovery is limited. We aimed to detect these changes with deformation imaging, hypothesizing that left ventricular global longitudinal (GLS) and circumferential strain (GCS) would remain impaired in the chronic phase despite normalization of ventricular function parameters assessed by two-dimensional echocardiography. A retrospective, single-institution review of 22 patients with MIS-C was performed. Fractional shortening, GLS, and GCS, along with regional longitudinal (RLS) and circumferential strain (RCS) were compared across the acute, subacute, and chronic timepoints (presentation, 14-42, and > 42 days, respectively). Mean GLS improved from - 18.4% in the acute phase to - 20.1% in the chronic phase (p = 0.4). Mean GCS improved from - 19.4% in the acute phase to - 23.5% in the chronic phase (p = 0.03). RCS and RLS were impaired in the acute phase and showed a trend towards recovery by the chronic phase, with the exception of the basal anterolateral segment. In our longitudinal study of MIS-C patients, GLS and GCS were lower in the acute phase, corroborating with left ventricular dysfunction by traditional measures. Additionally, as function globally recovers, GLS and GCS also normalize. However, some regional segments continue to have decreased strain values which may be an important subclinical marker for future adverse events.

关键词： BEAS-2B   MucilAir (TM)   Extractable organic matter   Exposure   Ethanol blend fuels  

摘要： Air pollution caused by road traffic has an unfavorable impact on the environment and also on human health. It has previously been shown, that complete gasoline emissions lead to toxic effects in cell models originating from human airways. Here we focused on extractable organic matter (EOM) from particulate matter, collected from gasoline emissions from fuels with different ethanol content. We performed cytotoxicity evaluation, quantification of mucin and extracellular reactive oxygen species (ROS) production, DNA breaks detection, and selected gene deregulation analysis, after one and five days of exposure of human bronchial epithelial model (BEAS-2B) and a 3D model of the human airway (MucilAir (TM)). Our data suggest that the longer exposure had more pronounced effects on the parameters of cytotoxicity and mucin production, while the impacts on ROS generation and DNA integrity were limited. In both cell models the expression of CYP1A1 was induced, regardless of the exposure period or EOM tested. Several other genes, including FMO2, IL1A, or TNF, were deregulated depending on the exposure time. In conclusion, ethanol content in the fuels did not significantly impact the toxicity of EOM. Biological effects were mostly linked to xenobiotics metabolism and inflammatory response. BEAS-2B cells were more sensitive to the treatment.

关键词： Opioid use disorder   Substance use disorders   Deep vein thrombosis   Thrombophlebitis  

摘要： Infected deep vein thrombophlebitis (i-DVT) in people who inject drugs (PWID) is a clinically challenging but poorly characterised disease. We undertook a retrospective observational study of 70 PWID presenting acutely with i-DVT to improve the clinical and microbiological characterisation of this disease. i-DVT was frequently associated with bacteraemia (59.1% patients with blood cultures obtained), groin abscesses (in 34.3%;of which 54.2% required surgical drainage), and septic pulmonary emboli (38.6%) requiring anticoagulation. Network analysis identified a cluster of patients presenting with respiratory symptoms but lacking typical DVT symptoms, more likely to have septic pulmonary emboli. A microbiologic diagnosis was frequently achieved (70%). Causative pathogens were predominantly gram-positive (S. aureus and streptococci, especially anginosus group), whereas gram-negative pathogens were identified very infrequently (in 6.1% of microbiological diagnoses). This suggests routine empiric therapy against gram-negative bacteria, though commonly administered, is not required. High rates of clinical cure (88.6%) were observed despite the complex nature of infections and independently of the highly variable intravenous and total antimicrobial durations received. There exists a rationale to devise pragmatic approaches to implement novel individualised treatment plans utilising oral antimicrobial therapy for i-DVT. Despite frequent healthcare interactions, opportunities to address HCV treatment and opioid substitution therapy were frequently missed during these acute admissions.

关键词： SARS-CoV   COVID-19   Diagnosis   Latin America   Algorithm  

摘要： Introduction: Latin America accounts for one-quarter of global COVID-19 cases and one-third of deaths. Inequalities in the region lead to barriers to the best use of diagnostic tests during the pandemic. There is a need for simplified guidelines that consider the region's limited health resources, international guidelines, medical literature, and local expertise. Methods: Using a modified Delphi method, 9 experts from Latin American countries developed a simplified algorithm for COVID-19 diagnosis on the basis of their answers to 24 questions related to diagnostic settings, and discussion of the literature and their experiences. Results: The algorithm considers 3 timeframes ( 7 days, 8-13 days, and 14 days) and presents diagnostic options for each. SARS-CoV-2 real- time reverse transcription-polymerase chain reaction is the test of choice from day 1 to 14 after symptom onset or close contact, although antigen testing may be used in specific circumstances, from day 5 to 7. Antibody assays may be used for confirmation, usually after day 14;however, if clinical suspicion is very high, but other tests are negative, these assays may be used as an adjunct to decision-making from day 8 to 13. Conclusion: The proposed algorithm aims to support COVID-19 diagnosis decision-making in Latin America. (c) 2021 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).